Evidence map›Paper›PMID 42334702›Full record

ArticleMolecular biology reports2026

Association of SIRT1 rs12778366 (T > C) polymorphism with reduced esophageal cancer risk: a case-control study from North India".

Jagmohan Singh Bali, Vasudha Sambyal, Sanjana Mehrotra, Kamlesh Guleria, Manjit Singh Uppal, Mridu Manjari, Meena Sudan

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Article in Molecular biology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

7 authors.

Jagmohan Singh BaliHuman Cytogenetics Laboratory, Department of Human Genetics, Guru Nanak Dev University, Amritsar, Punjab, India.ORCID http://orcid.org/0000-0001-5316-9086
Vasudha SambyalHuman Cytogenetics Laboratory, Department of Human Genetics, Guru Nanak Dev University, Amritsar, Punjab, India. vasuda.human@gndu.ac.in.ORCID http://orcid.org/0000-0002-6648-1906
Sanjana MehrotraHuman Cytogenetics Laboratory, Department of Human Genetics, Guru Nanak Dev University, Amritsar, Punjab, India.
Kamlesh GuleriaHuman Cytogenetics Laboratory, Department of Human Genetics, Guru Nanak Dev University, Amritsar, Punjab, India.
Manjit Singh UppalDepartment of Surgery, Sri Guru Ram Das Institute of Medical Sciences and Research, Vallah, Amritsar, Punjab, India.
Mridu ManjariDepartment of Pathology, Sri Guru Ram Das Institute of Medical Sciences and Research, Vallah, Amritsar, Punjab, India.
Meena SudanDepartment of Radiotherapy, Sri Guru Ram Das Institute of Medical Sciences and Research, Vallah, Amritsar, Punjab, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe protein histone deacetylase silent mating-type information regulator 2 homolog 1 (SIRT1) expression has been linked to cancer prognosis. However, reports evaluating the impact of SIRT1 polymorphisms on esophageal cancer (EC) risk or prognosis are limited. The present study aimed to assess the association between SIRT1 rs12778366 polymorphism and esophageal cancer. MATERIALS AND

methodsThe SIRT1 rs12778366 polymorphism was evaluated by PCR-RFLP method in 244 EC patients and 244 healthy controls from Punjab, India. Odds ratios with 95% confidence intervals were used to assess the association of rs12778366 with EC risk.

resultsThe CC genotype (OR = 0.34, 95% CI: 0.12-0.97, p = 0.04) and the C allele (OR = 0.66, 95% CI: 0.47-0.92, p = 0.01) of the SIRT1 rs12778366 polymorphism were significantly associated with a reduced risk of esophageal cancer.

conclusionPrevious studies have linked the SIRT1 rs12778366 polymorphism to susceptibility in breast, colorectal, and pituitary tumors, but its role in esophageal cancer has been minimally explored. In the present study, the CC genotype and C allele of SIRT1 rs12778366 were associated with a reduced risk of esophageal cancer in a North Indian population.

Indexed as

Esophageal NeoplasmsSirtuin 1AdultAgedAllelesCase-Control StudiesFemaleGene FrequencyGenetic Association StudiesGenetic Predisposition to DiseaseGenotypeHumansIndiaMaleMiddle AgedPolymorphism, Single NucleotideSIRT1 protein, humanSirtuin 1Cancer susceptibilityEsophageal cancerGenetic polymorphismPolymorphismSIRT1

Identifiers

PMID42334702

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.