ArticleClinical oral investigations2026
A proof-of-concept for a novel mandibular dental implant model in mice.
Article in Clinical oral investigations, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
aimsAnimal models are needed to further investigate the osseointegration process after dental implant placement. The aim of this study was to introduce a proof-of-concept for a novel preclinical mandibular dental implant in mice.
methodsMorphometric analyses of maxillaries from C57BL/6 mice were performed using micro-computed tomography (micro-CT) to identify suitable implant site. The bone surrounding the mandibular first molar was selected due to its similarity to human bone characteristics (cortical/trabecular bone and crown/root ratio), and vertical shape which allows for implant complete bone coverage. Considering dental development and alveolar bone density, mandibular first molars were extracted 5 weeks postnatally. Implants were designed based on the characteristics of the alveolar bone healing site and manufactured in medical Ti-6Al-4 V. One implant was placed per mouse at the tooth extraction site and maintained to 35 days post-extraction. Bone-to-implant contact was measured by longitudinal micro-CT imaging.
resultsFollowing morphometric evaluation, the mandibular first molar site was selected for implant placement based on its sufficient bone volume. Five weeks after extraction, the surgical site showed a bone volume-to-total volume ratio similar to that of native bone (83% vs. 84%, respectively). Implant follow-up showed that peri-implant bone volume plateaued from day 28 and indicated intimate contact between bone and implant surfaces (84.6%) at day 35 after implantation, confirmed through histological analyses.
conclusionThis proof-of-concept study establishes a reliable preclinical mouse model for mandibular dental implantation. Beyond implantology, this model offers promising applications for investigating how systemic or genetic conditions influence bone healing and implant success.
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