SynthesisCurrent pain and headache reports2026
A Systematic Review and Meta-Analysis of Randomized Controlled Trials of Epidural Regenerative Medicine Therapies in Managing Spinal Pain.
Synthesis in Current pain and headache reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purpose of reviewThis review aims to assess the effectiveness of epidural injections of mesenchymal stem cells (MSCs) and platelet-rich plasma (PRP) in treating chronic spinal pain. While existing literature has primarily concentrated on intradiscal regenerative therapies, this systematic review focuses specifically on the efficacy of PRP and MSCs when administered into the epidural space for managing chronic spinal pain. RECENT
findingsDue to their anti-inflammatory and regenerative properties, emerging studies underscore the therapeutic promise of epidural biologics, including MSCs, platelet-rich plasma, and alpha-2-macroglobulin. Epidural administration offers key advantages: it avoids the risk of discitis and minimizes the chance of disc injury from needle penetration. Moreover, this route enables simultaneous treatment of multiple affected discs without discography or multiple intradiscal injections. This is particularly relevant in elderly patients who often present with advanced disc degeneration and narrowed disc spaces, making intradiscal injections technically difficult. Clinical findings suggest notable improvements in pain reduction, physical functionality, and overall quality of life following these epidural treatments. A total of 9 randomized controlled trials (RCTs) were included in the review to evaluate epidural biologics for chronic spinal pain management. No RCTs investigating stem cells were identified. The quality of evidence was rated as fair (Level III), with moderate effect size and recommendation strength based on a qualitative synthesis and GRADE (Grading of Recommendations, Assessment, Development and Evaluations) methodology.
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Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.