Evidence map›Paper›PMID 42334667›Full record

Trial reportTechniques in coloproctology2026

Evaluation of the efficacy of a Propionibacterium extract gel in wound healing and symptom relief after open excisional hemorrhoidectomy: a randomized clinical study.

S Deidda, C Eberspacher, V Argiolas, L Ventrone, A Testa, S Ascanelli, E Rossin, G Lisi, D Mascagni, L Zorcolo

Registry-linked trialAbstract readRandomized Controlled TrialMulticenter StudyClinical Trial, Phase IV
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Techniques in coloproctology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06872151 (Evaluation of the Effectiveness of a Gel Containing a Propionibacterium Extract in Wound Healing and Symptom Relief, Such as Pain, Itching, and Burning, in the Postoperative Period of Open Excisional Hemorrhoidectomy), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06872151 phase4completednot on this map

Evaluation of the Effectiveness of a Gel Containing a Propionibacterium Extract in Wound Healing and Symptom Relief, Such as Pain, Itching, and Burning, in the Postoperative Period of Open Excisional Hemorrhoidectomy

TypeinterventionalSponsorUniversity of CagliariRan2025 to 2025Enrolled114ConditionsAnus Diseases, Gastrointestinal Diseases, Intestinal Diseases, CicatrizationArmsGel containing a Propionibacterium extract, Hyaluronic acid and silver sulfadiazine
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

S DeiddaColorectal Surgery Unit, Department of Surgical Science, A.O.U. Cagliari, University of Cagliari, Monserrato, S.S. 554 Bivio Sestu, 09042, Cagliari, Italy. simona.deidda86@unica.it.ORCID http://orcid.org/0000-0002-7756-9727
C EberspacherDepartment of Surgery, "Sapienza" University of Rome, Rome, Italy.
V ArgiolasColorectal Surgery Unit, Department of Surgical Science, A.O.U. Cagliari, University of Cagliari, Monserrato, S.S. 554 Bivio Sestu, 09042, Cagliari, Italy.
L VentroneDepartment of Surgery, "Sapienza" University of Rome, Rome, Italy.
A TestaChirurgia Generale, Ospedale San Pietro FBF, Rome, Italy.
S AscanelliSurgical Department, University Hospital, Ferrara, Italy.
E RossinSurgical Department, University Hospital, Ferrara, Italy.
G LisiDepartment of Surgery, Sant'Eugenio Hospital, Viale Dell'Umanesimo 10, Rome, Italy.
D MascagniDepartment of Surgery, "Sapienza" University of Rome, Rome, Italy.
L ZorcoloColorectal Surgery Unit, Department of Surgical Science, A.O.U. Cagliari, University of Cagliari, Monserrato, S.S. 554 Bivio Sestu, 09042, Cagliari, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPostoperative symptoms such as pain, burning, and itching are common following open excisional hemorrhoidectomy and are often associated with several factors, including wound healing. This study evaluated the efficacy of Propionibacterium extract gel (PeG) in promoting wound healing and reducing pain, burning, and itching compared to an ointment containing hyaluronic acid and silver sulfadiazine (HA-SSD).

methodsIn this multicenter, phase IV randomized controlled trial, patients undergoing open excisional hemorrhoidectomy were randomly assigned in a 1:1 ratio to receive PeG or HA-SSD. The primary outcome (wound healing) was evaluated on the basis of grade of epithelialization. Secondary outcomes (pain, burning, and itching) were assessed using a 10-point visual analogue scale at baseline and 10, 20, and 40 days postoperatively.

resultsOf the 119 screened patients, 64 (53.78%) received PeG and 55 (46.22%) received HA-SSD. The baseline characteristics were comparable. After 20 days, 46 (75.4%) of the PeG group patients had an epithelialization grade > 50% (vs n = 37, 72.6% of the HA-SSD group; p = 0.02). By day 40, complete wound healing occurred in 52 (85.3%) of the PeG group patients (vs n = 25, 52.1% of the HA-SSD group; p = 0.003). Both treatments reduced postoperative pain over time, with no significant between-group difference (p = 0.24). PeG demonstrated a superior reduction in burning (p = 0.02) and itching (p = 0.001). Patient satisfaction was higher with PeG (n = 45, 75% vs n = 9, 18.8% of the HA-SSD group, p < 0.001), with no reported adverse reactions.

conclusionsPeG was more efficient than HA-SSD in promoting wound healing, alleviating burning and itching, and enhancing patient satisfaction following hemorrhoidectomy. This study supports the safety and effectiveness of PeG as a therapeutic option for postoperative management. CLINICAL

trial registrationNCT06872151, retrospectively registered on 6 March 2025.

Indexed as

HemorrhoidectomyPostoperative PainWound HealingAdultFemaleGelsHemorrhoidsHumansHyaluronic AcidMaleMiddle AgedPain MeasurementPruritusTreatment OutcomeGelsHyaluronic AcidColorectal surgeryHemorrhoidectomyPatient satisfactionPostoperative painTopical therapyWound healing

Identifiers

PMID42334667
PMCPMC13547177

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.