Evidence map›Paper›PMID 42334541›Full record

ReviewAdvances in experimental medicine and biology2026

PCNA Macromolecular Complexes: PCNA Serves as a Molecular Hub Regulating Multiple Cellular Processes Inside and Outside of the Nucleus.

Hamsini Kala, Dana Abou Abbas, Linda H Malkas, Robert J Hickey

Abstract readReview
PubMed Publisher
In one paragraph

Review in Advances in experimental medicine and biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Hamsini KalaIrell & Manella Graduate School of Biological Sciences, Department of Cancer Biology and Molecular Medicine, Beckman Research Institute of City of Hope, Duarte, CA, USA.
Dana Abou AbbasIrell & Manella Graduate School of Biological Sciences, Department of Molecular Diagnostics and Experimental Therapeutics, Beckman Research Institute of City of Hope, Duarte, CA, USA.
Linda H MalkasDepartment of Molecular Diagnostics and Experimental Therapeutics, Beckman Research Institute of City of Hope, Duarte, CA, USA.
Robert J HickeyDepartment of Cancer Biology and Molecular Medicine, Beckman Research Institute of City of Hope, Duarte, CA, USA. rohickey@coh.org.

Funding

Transgenic Mouse FacilityP30CA033572 · NCI · CITY OF HOPE/BECKMAN RESEARCH INSTITUTE · PI John Charles Williams · 1985 to 2026
$86.3M
NCI NIH HHS P30 CA033572
6 · The paper itself

Abstract

With over 27,100 papers currently written about Proliferating Cell Nuclear Antigen (PCNA) and more than 11,700 papers describing a role for the protein and its relationship to cancer, this chapter will just touch upon some of the important role's PCNA has within cells and what types of proteins might interact with PCNA. This chapter is not meant to provide a thorough review of the multitude of protein complexes utilizing PCNA as a cofactor but rather highlight only some of those direct or indirect interactions between PCNA and its binding partners which together are involved in maintaining the genome, regulating cytoplasmic activities, and participating in immune surveillance. Additionally, this chapter will provide a high-level overview of how the caPCNA isoform is being used as a platform for a new class of anticancer therapeutic agent that selectively kills cancer cells, while leaving non-cancer cells unharmed.

Indexed as

Cell NucleusNeoplasmsProliferating Cell Nuclear AntigenAnimalsDNA ReplicationHumansProtein BindingPCNA protein, humanProliferating Cell Nuclear AntigenCancer-associated PCNA isoformDNA replication and repairGenome stabilityImmune surveillancePost-translational modificationsProliferating cell nuclear antigenProtein-protein interactionsReplication stressSmall-molecule inhibitors

Identifiers

PMID42334541

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.