ReviewAdvances in experimental medicine and biology2026
Dynamic Assemblies in Genome Maintenance.
Review in Advances in experimental medicine and biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
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Authors and funding
2 authors.
Funding
Abstract
The integrity of the human genome is continuously challenged by diverse endogenous and exogenous threats that damage DNA and disrupt its replication. When the replication machinery encounters such obstacles, including lesions or non-canonical DNA structures, it may stall, initiate repair, or activate specialized pathways to bypass the impediment. Maintaining replication progression requires a coordinated and dynamic assembly of numerous nucleoprotein complexes that recognize, process, and resolve DNA damage and replication stalling structures. This chapter highlights how proliferating cell nuclear antigen (PCNA), poly(ADP-ribose) polymerase 1 (PARP1), and non-canonical DNA structures are integrated into higher-order supramolecular complexes that stabilize, remodel, or resolve stalled or damaged replication forks. The molecular events carried out by these supramolecular complexes are essential for preserving genomic integrity in human cells. Moreover, many of the factors involved emerge as attractive therapeutic targets for diseases driven by genome instability, including cancer.
Indexed as
Identifiers
42334540What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.