Evidence map›Paper›PMID 42334535›Full record

ArticleAdvances in experimental medicine and biology2026

Introduction.

Stephen J Benkovic

Abstract read
PubMed Publisher
In one paragraph

Article in Advances in experimental medicine and biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Stephen J BenkovicDepartment of Chemistry, The Pennsylvania State University, University Park, PA, USA. sjb1@psu.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Owing to a lengthy career, I occupied a ringside seat to watch the evolution of our understanding of enzymatic catalysis. The field has progressed from primitive bioorganic models of enzyme active sites, which guided physical organic-based studies on how enzymes hydrolyze esters and amides, as well as laborious purifications of individual enzymes from animal organs, to investigations of multienzyme complexes, as featured in this text. My intent in this short essay is to provide background for the chapters in this volume. What papers and texts might have inspired the research reported within them? Where was the field at that time, and where might it be going?

Indexed as

EnzymesMultienzyme ComplexesAnimalsCatalytic DomainHumansEnzymesMultienzyme ComplexesBioorganic chemistryEnzyme compartmentalizationEnzymologyMetabolonsMulti-enzyme complexesPurinosomeReplisome

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.