ArticleInternational urology and nephrology2026
Low-intensity shock wave therapy for penile rehabilitation in patients with erectile dysfunction following pelvic fracture urethral injury: a pilot study.
Article in International urology and nephrology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07460167 (Penile Rehabilitation in Patients With Erectile Dysfunction After Pelvic Fracture Urethral Injury Using Low-intensity Shock Wave), which is not on this map. Not yet cited in PubMed.
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Penile Rehabilitation in Patients With Erectile Dysfunction After Pelvic Fracture Urethral Injury Using Low-intensity Shock Wave: A Pilot Study.
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4 authors.
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Abstract
purposePelvic fracture urethral injury (PFUI) frequently results in long-term erectile dysfunction (ED), severely impacting quality of life. Low-intensity shockwave therapy (LiSWT) promotes neovascularization and tissue perfusion via VEGF and nitric oxide pathways, offering a potential regenerative treatment for post-traumatic ED. This study aims to evaluate the efficacy and safety of LiSWT for ED secondary to urethral injury from pelvic fractures.
methodsThis pilot study included 25 men with ED post-PFUI. Participants received six weekly sessions of LiSWT (24,000 shocks total) using a piezoelectric device. Assessments included the International Index of Erectile Function (IIEF) and Erectile Hardness Scale (EHS) at baseline and at 3, 6, and 12 months' post-treatment, while penile Doppler ultrasound was done at baseline and 12 months' post-treatment.
resultsIIEF scores improved significantly from 14.4 ± 3.2 at baseline to 17.4 ± 3.2 (p = 0.002) post-LiSWT, 16.4 ± 3.2 (p = 0.036) at 3 months, 17.4 ± 3.2 (p = 0.002) at 6 months, and 17.8 ± 3.7 (p < 0.001) at 12 months. EHS increased significantly at all follow-ups (p < 0.001), with a further rise between 3 months 2.35 ± 0.53 and 12 months 2.74 ± 0.58 (p = 0.009). PSV increased from 23.4 ± 6.1 at baseline to 34.1 ± 9.1 (p < 0.001) at 12 months, EDV decreased from 6.68 ± 2.95 at baseline to 3.84 ± 2.70 (p = 0.002) at 12 months, and RI increased from 0.66 ± 0.22 at baseline to 0.86 ± 0.13 (p < 0.001) at 12 months.
conclusionLiSWT is safe and effective for ED after PFUI, producing sustained improvements in erectile function, penile rigidity, and hemodynamics, representing a promising noninvasive therapeutic option for post-traumatic ED.
trial registrationClinicalTrials.gov NCT07460167, registered 10 March 2026, retrospectively registered.
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