Evidence map›Paper›PMID 42334513›Full record

ArticleJournal of ophthalmic inflammation and infection2026

Nocardia brasiliensis endophthalmitis initially misdiagnosed as uveitis: a case report.

Xue Zhang, Liping Du, Xuemin Jin, Jingjing Sun, Guangqi An, Lin Li, Peizeng Yang, Fuzhen Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of ophthalmic inflammation and infection, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Xue ZhangDepartment of Ophthalmology, The First Affiliated Hospital of Zhengzhou University, Henan Province Eye Hospital, Henan International Joint Research Laboratory for Ocular Immunology and Retinal Injury Repair, Henan Province Engineering Research Center of Fundus Disease and Ocular Trauma Prevention and Treatment, Zhengzhou, 450052, China.
Liping DuDepartment of Ophthalmology, The First Affiliated Hospital of Zhengzhou University, Henan Province Eye Hospital, Henan International Joint Research Laboratory for Ocular Immunology and Retinal Injury Repair, Henan Province Engineering Research Center of Fundus Disease and Ocular Trauma Prevention and Treatment, Zhengzhou, 450052, China.
Xuemin JinDepartment of Ophthalmology, The First Affiliated Hospital of Zhengzhou University, Henan Province Eye Hospital, Henan International Joint Research Laboratory for Ocular Immunology and Retinal Injury Repair, Henan Province Engineering Research Center of Fundus Disease and Ocular Trauma Prevention and Treatment, Zhengzhou, 450052, China.
Jingjing SunDepartment of Clinical Laboratory, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Guangqi AnHenan Provincial People's Hospital, Zhengzhou University People's Hospital, Henan Eye Hospital, Zhengzhou, China.
Lin LiDepartment of Ophthalmology, The First Affiliated Hospital of Zhengzhou University, Henan Province Eye Hospital, Henan International Joint Research Laboratory for Ocular Immunology and Retinal Injury Repair, Henan Province Engineering Research Center of Fundus Disease and Ocular Trauma Prevention and Treatment, Zhengzhou, 450052, China.
Peizeng YangDepartment of Ophthalmology, The First Affiliated Hospital of Zhengzhou University, Henan Province Eye Hospital, Henan International Joint Research Laboratory for Ocular Immunology and Retinal Injury Repair, Henan Province Engineering Research Center of Fundus Disease and Ocular Trauma Prevention and Treatment, Zhengzhou, 450052, China.
Fuzhen LiDepartment of Ophthalmology, The First Affiliated Hospital of Zhengzhou University, Henan Province Eye Hospital, Henan International Joint Research Laboratory for Ocular Immunology and Retinal Injury Repair, Henan Province Engineering Research Center of Fundus Disease and Ocular Trauma Prevention and Treatment, Zhengzhou, 450052, China. fcclifz@zzu.edu.cn.

Funding

First Affiliated Hospital of Zhengzhou University 2025Hx39Health Commission of Henan Province SBGJ202101011Henan Provincial Health Commission YXKC2020026National Natural Science Foundation of China 82101108National Natural Science Foundation of China 82230032National Natural Science Foundation of China 82301271
6 · The paper itself

Abstract

backgroundEndophthalmitis caused by Nocardia brasiliensis is extremely rare and typically affects immunocompromised individuals, frequently leading to severe vision loss due to diagnostic delays. We report a case of N. brasiliensis endophthalmitis in an older man without prior history of systemic immunosuppression but with newly identified diabetes mellitus, characterized by an indolent initial course followed by fulminant progression. CASE PRESENTATION: A 67-year-old man without known systemic immunosuppression presented with a two-month history of recurrent right-eye pain and redness, followed by rapid vision loss and a hypopyon. Aqueous humor analysis and metagenomic sequencing identified N. brasiliensis. Despite intravitreal amikacin, systemic antimicrobial therapy, and subsequent pars plana vitrectomy with silicone oil tamponade, intraocular inflammation advanced, resulting in worsening corneal opacification, irreversible structural damage, and a final best-corrected visual acuity of light perception.

conclusionsN. brasiliensis endophthalmitis may progress rapidly and result in severe, irreversible ocular damage, even in patients without overt systemic immunodeficiency. Early microbiologic identification and prompt, targeted antimicrobial therapy combined with timely surgical intervention are critical, although visual outcomes may remain poor in advanced cases.

Indexed as

EndophthalmitisMetagenomic next-generation sequencingNocardia brasiliensisUveitis

Identifiers

PMID42334513
PMCPMC13547206

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.