Evidence map›Paper›PMID 42334485›Full record

ArticleACS chemical neuroscience2026

Discovery of VU6066098: A Selective and CNS-Penetrant mGlu

Jeremy S Coleman, Rory A Capstick, Sichen Chang, Derek J Rios, Michael Bubser, Analisa D Thompson Gray, Irene Zagol-Ikapitte, Srinivasan Krishnan, Hyekyung P Cho, Alice L Rodriguez and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS chemical neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Jeremy S ColemanWarren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.ORCID 0000-0002-1005-3355
Rory A CapstickWarren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.
Sichen ChangWarren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.
Derek J RiosWarren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.
Michael BubserWarren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.
Analisa D Thompson GrayWarren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.
Irene Zagol-IkapitteWarren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.
Srinivasan KrishnanWarren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.
Hyekyung P ChoWarren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.
Alice L RodriguezWarren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.ORCID 0000-0002-5244-5103
Colleen M NiswenderWarren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.ORCID 0000-0001-6009-8212
Olivier BoutaudWarren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.
Georgina Perez GarciaResearch and Development Service, James J. Peters Department of Veterans Affairs Medical Center, 130 West Kingsbridge Road, Bronx, New York, New York 10468, United States.
Gregory A ElderDepartment of Neurology, Icahn School of Medicine at Mount Sinai, One Gustave Levy Place, New York, New York 10029, United States.
Darren W EngersWarren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.
Carrie K JonesWarren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.
Craig W LindsleyWarren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.ORCID 0000-0003-0168-1445

Funding

BLRD VA I01 BX005882RRD VA I01 RX003846
6 · The paper itself

Abstract

Herein, we report the discovery and development of an optimized mGlu

Indexed as

Antidepressive AgentsAntipsychotic AgentsNootropic AgentsReceptors, Metabotropic GlutamateAllosteric RegulationAnimalsMaleRatsRats, Sprague-DawleyAntidepressive AgentsAntipsychotic Agentsmetabotropic glutamate receptor 2Nootropic AgentsReceptors, Metabotropic Glutamateamphetamine-induced hyperlocomotion (AHL)blast-related traumatic brain injury (TBI)contextual fear conditioning (CFC)depressionforced swimmetabotropic glutamate receptor subtype 2 (mGlu2)negative allosteric modulator (NAM)novel object recognition (NOR)

Identifiers

PMID42334485
PMCPMC13377601

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.