ReviewHuman vaccines & immunotherapeutics2026
Understanding the roots of hesitancy to unlock the game-changing impact of HPV vaccination: Insights from a global qualitative evidence synthesis.
Review in Human vaccines & immunotherapeutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- The Cancer That Could Disappear.Clinical journal of oncology nursing · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The human papillomavirus (HPV) vaccine is one of the most powerful tools in cancer prevention and is central to global efforts to eliminate cervical cancer as a public health problem. Yet worldwide uptake remains suboptimal. Our 2025 Cochrane qualitative evidence synthesis - comprising 71 studies from diverse geographic and socioeconomic settings - provides the most comprehensive global understanding to date of caregivers' and adolescents' views and practices regarding HPV vaccination, and the reasons why some are reluctant to receive the vaccine. Our review found HPV vaccine decision-making to be influenced by a complex web of socio-cultural, political and trust-related factors, beyond awareness or a simple evaluation of vaccine benefits and risks. We synthesized these factors into eight overarching themes. Together these provide a novel conceptual framework of the multi-level, interacting influencing factors, distinguishing it from more narrow, individual HPV vaccination acceptance frameworks. In this commentary we describe this conceptual framework and propose how it might be used to inform strategies for improving HPV vaccine uptake in ways that are more person-centered, equitable and ultimately effective. As countries worldwide aim to upscale and optimize HPV vaccination programs, incorporating insights from this review into HPV vaccination policy, program design and service delivery is essential and urgent.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.