Evidence map›Paper›PMID 42334134›Full record

ArticleJournal of child and adolescent psychopharmacology2026

Low Emotional Awareness and Altered Frontostriatal Functional Connectivity During Reward Processing Prospectively Predict Depressive Symptoms in At-Risk Youth.

T H Stanley Seah, Tina Gupta, Carly J Lenniger, Kristen L Eckstrand, Manivel L Rengasamy, Chloe M Horter, Morgan B Lindenmuth, Melissa Nance, Erika E Forbes

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In one paragraph

Article in Journal of child and adolescent psychopharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

T H Stanley SeahDepartment of Psychology, Miami University, Oxford, Ohio, USA.ORCID 0000-0002-8042-8319
Tina GuptaDepartment of Psychology, University of Oregon, Eugene, Oregon, USA.
Carly J LennigerDepartment of Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Kristen L EckstrandDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Manivel L RengasamyDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Chloe M HorterDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Morgan B LindenmuthDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Melissa NanceDepartment of Psychology, University of Notre Dame, Notre Dame, Indiana, USA.
Erika E ForbesDepartment of Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

Funding

University of Pittsburgh Clinical and Translational Science InstituteUL1TR001857 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2016 to 2025
$129.3M
Institutional Career Development CoreKL2TR001856 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI RAY, KRISTIN N, RUBIO, DORIS M · 2016 to 2025
$13.8M
CLINICAL RESEARCH TRAINING IN CHILD PSYCHIATRYT32MH018951 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI TINA R GOLDSTEIN · 1990 to 2026
$9.7M
Development of Anhedonia in High-Risk AdolescentsR01MH104418 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FORBES, ERIKA E · 2015 to 2020
$3.1M
Neural circuitry underlying emotional abuse and depression in sexual minority youthK23MH128728 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KRISTEN ECKSTRAND · 2022 to 2026
$940k
Combining ecological momentary assessment and qualitative methods to construct a theoretical model of acute alcohol use and non-suicidal self-injuryF31AA031894 · NIAAA · UNIVERSITY OF NOTRE DAME · PI Melissa Nance · 2025 to 2026
$100k
NCATS NIH HHS KL2 TR001856NCATS NIH HHS UL1 TR001857NIAAA NIH HHS F31 AA031894NIMH NIH HHS K23 MH128728NIMH NIH HHS R01 MH104418NIMH NIH HHS T32 MH018951
6 · The paper itself

Abstract

objectiveTo examine how emotional awareness (the ability to understand and identify one's own emotions) and neural reward circuitry, processes that are associated with depression and undergo significant maturation during adolescence, prospectively predict depressive symptoms in a community sample of youth at varying risk for affective disorders.

methodYouth aged 13-19 years (

resultsLow emotional awareness at baseline predicted more severe depressive symptoms at 1-year follow-up, particularly among youth demonstrating heightened positive dmPFC-NAcc functional connectivity, a pattern potentially indicating over-regulation of reward responding. DISCUSSION: Low emotional awareness and stronger frontostriatal functional connectivity during processing of reward relative to loss are relevant early-emerging risk factors that could jointly lead to future depression. Interventions targeting emotional regulation skills and reward processing may mitigate the onset and course of adolescent depressive symptoms.

Indexed as

AwarenessDepressionEmotionsNucleus AccumbensPrefrontal CortexRewardAdolescentFemaleFollow-Up StudiesHumansMagnetic Resonance ImagingMaleProspective StudiesYoung Adultadolescencedepressionemotion awarenessemotion regulationneuroimagingreward

Identifiers

PMID42334134
PMCPMC13559752

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.