ArticleJournal of magnetic resonance imaging : JMRI2026
Postprandial Changes in Thoracic Aortic Flow Detected by 4D Flow MRI May Influence Study Results.
Article in Journal of magnetic resonance imaging : JMRI, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundWhile there is a growing body of data using 4D flow MRI to distinguish between normal and abnormal blood flow values in the thoracic aorta, the extent of physiological variation or lack thereof is potentially undervalued. Physiological processes such as postprandial changes to hemodynamics might influence data, normal values, follow-up studies, and data compared between study sites. PURPOSE: To determine the influence of food intake on flow parameters in the thoracic aorta of young healthy volunteers by 4D flow MRI. STUDY TYPE: Prospective. SUBJECTS: 20 young healthy (10 male, 10 female) volunteers were recruited for this study. FIELD STRENGTH/SEQUENCE: 3T/4D flow MRI (three-dimensional time-resolved phase-contrast spoiled gradient-echo with three-directional velocity-encoding). Technical parameters were chosen according to consensus recommendations, including the use of a respiratory navigator, included a 10 mm respiratory navigator window, retrospective ECG gating, VENC 180-200 cm/s, voxel size 2.5 × 2.5 × 2.0-2.5 mm ASSESSMENT: Volunteers' thoracic aorta was imaged after fasting (food ≥ 6 h, liquid ≥ 2 h) and after a meal challenge to detect changes in aortic hemodynamics (stroke volume, flow, and velocity). STATISTICAL TESTS: Statistics included calculation of relative difference (RD), two-tailed paired t-test, and Pearson coefficient. p < 0.05 was considered significant.
results4D flow MRI detected statistically significant postprandial increases in stroke volume (pre: 93 ± 18 mL; post: 99 ± 24 mL, RD = 5 ± 13%), peak flow (pre: 433 ± 95 mL/s; post: 467 ± 95 mL/s, RD = 9 ± 14%), peak average velocity (pre: 73 ± 18 cm/s; post: 78 ± 16 cm/s, RD = 8 ± 11%), and maximum velocity (pre: 118 ± 24 cm/s; post: 131 ± 23 cm/s, RD = 11 ± 11%); values given for ascending aorta. 74% of individuals presented with postprandial increase in peak flow and velocities throughout the thoracic aorta. DATA
conclusionFood intake triggers a small but significant increase in stroke volume, flow, and velocity in the aorta in young healthy individuals. Depending on the study question and potential longitudinal comparisons, one may consider introducing a fasting period prior to 4D flow MRI to avoid measurements at peak postprandial hyperemia. EVIDENCE LEVEL: 2. TECHNICAL EFFICACY: Stage 3, diagnostic thinking.
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