Evidence map›Paper›PMID 42333976›Full record

ArticleJournal of magnetic resonance imaging : JMRI2026

Standardized MRI-Based Quantification of Epicardial Adipose Tissue Volume: Reproducibility and Agreement With Cardiac Computed Tomography.

Judith Gronwald, Svante S Gersch, Zoé Böttiger, Clara Hagedorn, Torben Lange, Sören J Backhaus, Sebastian Kelle, Constanze Schmidt, Karl Toischer, Andreas Schuster and 1 more

Abstract read
In one paragraph

Article in Journal of magnetic resonance imaging : JMRI, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Judith GronwaldDepartment of Cardiology and Pneumology, University Medical Center Göttingen, Georg-August University and German Center for Cardiovascular Research (DZHK), Partner Site Lower-Saxony, Göttingen, Germany.ORCID https://orcid.org/0009-0000-4953-1409
Svante S GerschDepartment of Cardiology and Pneumology, University Medical Center Göttingen, Georg-August University and German Center for Cardiovascular Research (DZHK), Partner Site Lower-Saxony, Göttingen, Germany.
Zoé BöttigerDepartment of Cardiology and Pneumology, University Medical Center Göttingen, Georg-August University and German Center for Cardiovascular Research (DZHK), Partner Site Lower-Saxony, Göttingen, Germany.
Clara HagedornDepartment of Cardiology and Pneumology, University Medical Center Göttingen, Georg-August University and German Center for Cardiovascular Research (DZHK), Partner Site Lower-Saxony, Göttingen, Germany.ORCID https://orcid.org/0009-0005-9427-7960
Torben LangeDepartment of Cardiology and Pneumology, University Medical Center Göttingen, Georg-August University and German Center for Cardiovascular Research (DZHK), Partner Site Lower-Saxony, Göttingen, Germany.ORCID https://orcid.org/0000-0003-0505-2582
Sören J BackhausDepartment of Cardiology, Campus Kerckhoff of the Justus-Liebig-University Giessen, Kerckhoff-Heart-Centre, Bad Nauheim, Germany.ORCID https://orcid.org/0000-0002-2683-6418
Sebastian KelleDepartment of Internal Medicine/Cardiology, Charité Campus Virchow Clinic, Berlin, Germany.ORCID https://orcid.org/0000-0001-8105-6599
Constanze SchmidtDepartment of Cardiology and Pneumology, University Medical Center Göttingen, Georg-August University and German Center for Cardiovascular Research (DZHK), Partner Site Lower-Saxony, Göttingen, Germany.ORCID https://orcid.org/0000-0001-5897-237X
Karl ToischerDepartment of Cardiology and Pneumology, University Medical Center Göttingen, Georg-August University and German Center for Cardiovascular Research (DZHK), Partner Site Lower-Saxony, Göttingen, Germany.
Andreas SchusterFORUM Medizin, Kardiologie, Rosdorf, Germany.ORCID https://orcid.org/0000-0003-1508-1125
Alexander SchulzDepartment of Cardiology and Pneumology, University Medical Center Göttingen, Georg-August University and German Center for Cardiovascular Research (DZHK), Partner Site Lower-Saxony, Göttingen, Germany.

Funding

German Research Foundation CRC 1002University Medical Center Göttingen
6 · The paper itself

Abstract

backgroundEpicardial adipose tissue volume (EATV) is increasingly recognized as a cardiometabolic risk marker associated with adverse outcomes. The most established approach for EATV quantification is cardiac computed tomography (CT). MRI offers a radiation-free alternative allowing simultaneous assessment of myocardial function and tissue characteristics; however, standardization and validation are limited. PURPOSE: To evaluate a standardized MRI-based method for EATV quantification and determine its agreement with CT. STUDY TYPE: Retrospective. POPULATION: 127 patients with aortic stenosis (AS) (78 ± 6 years; 38% female) who underwent paired CT and MRI and 11 volunteers (74 ± 7 years, 45% female) who underwent repeat MRI after ≥ 6 weeks. FIELD STRENGTH/SEQUENCE: Short-axis balanced steady-state free precession cine sequence at 3T (AS patients) and 1.5T (volunteers). ASSESSMENT: On CT, EATV was quantified by manual delineation of the visceral pericardium and voxel-thresholding (-190 to -30 HU). MRI-based EATV quantification used manual volumetry with delineation of the visceral pericardium and epicardium on end-diastolic short-axis cine stacks. STATISTICAL TESTS: Inter-modality agreement was assessed by Spearman correlation and Bland-Altman analysis. Reproducibility was evaluated in 20 patients using intraclass correlation coefficient (ICC) and coefficient of variation (CoV). Scan-rescan reproducibility for MRI-derived EATV quantification was assessed using ICC and linear regression. p < 0.05 was considered significant.

resultsMedian EATV was significantly higher on MRI than CT (47 vs. 38 mL/m DATA

conclusionThe standardized MRI-based approach enabled highly reproducible EATV measurements with excellent repeatability. Agreement with CT was moderate, with systematically higher values on MRI, limiting direct comparability. EVIDENCE LEVEL: 3. STAGE OF TECHNICAL EFFICACY: 2.

Indexed as

Adipose TissueAortic Valve StenosisEpicardial Adipose TissueMagnetic Resonance ImagingPericardiumTomography, X-Ray ComputedAgedAged, 80 and overFemaleHumansImage Processing, Computer-AssistedMagnetic Resonance Imaging, CineMaleReproducibility of ResultsRetrospective Studiescardiac CTcardiac MRIepicardial adipose tissuestandardizationvalidation

Identifiers

PMID42333976
PMCPMC13578556

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.