Evidence map›Paper›PMID 42333929›Full record

ArticleAngewandte Chemie (International ed. in English)2026

Cobalt-Catalyzed Radical Ligand Transfer (RLT) Enables Remote-Markovnikov Hydroamination of Alkenes.

Arman Khosravi, Ho Martin Yuen, Seth Fremin, Nuwan A Pannilawithana, Nol Supasueb, Yu Zhang, Peng Liu, Ming-Yu Ngai

Abstract read
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In one paragraph

Article in Angewandte Chemie (International ed. in English), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Arman KhosraviJames Tarpo Jr. and Margaret Tarpo Department of Chemistry, Purdue University, West Lafayette, Indiana, USA.
Ho Martin YuenJames Tarpo Jr. and Margaret Tarpo Department of Chemistry, Purdue University, West Lafayette, Indiana, USA.
Seth FreminDepartment of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Nuwan A PannilawithanaJames Tarpo Jr. and Margaret Tarpo Department of Chemistry, Purdue University, West Lafayette, Indiana, USA.
Nol SupasuebJames Tarpo Jr. and Margaret Tarpo Department of Chemistry, Purdue University, West Lafayette, Indiana, USA.
Yu ZhangDepartment of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Peng LiuDepartment of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID https://orcid.org/0000-0002-8188-632X
Ming-Yu NgaiJames Tarpo Jr. and Margaret Tarpo Department of Chemistry, Purdue University, West Lafayette, Indiana, USA.ORCID https://orcid.org/0000-0002-3055-6662

Funding

Novel Strategies and Reagents for Introduction of Fluorinated GroupsR35GM119652 · NIGMS · STATE UNIVERSITY NEW YORK STONY BROOK · PI Ming-Yu Ngai · 2016 to 2026
$4.8M
Computational Models for Reactivity and Selectivity in Transition Metal-Catalyzed Olefin FunctionalizationR35GM128779 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Peng Liu · 2018 to 2026
$2.9M
National Science Foundation OAC-1928147National Science Foundation OAC-1928224National Science Foundation OAC-2117681National Science Foundation Graduate Research Fellowship 2139321NIGMS NIH HHS R35 GM119652NIGMS NIH HHS R35 GM128779NIH HHS R35-GM119652NIH HHS R35-GM128779
6 · The paper itself

Abstract

Amino alcohols are prevalent in pharmaceuticals, agrochemicals, and functional materials, yet regioselective remote C─N bond formation from simple alkenes remains limited. We report a remote-Markovnikov formal 1,3-hydroamination of allyl carboxylates enabled by cooperative photoredox, cobalt, and Brønsted acid catalysis. The reaction proceeds via metal-hydride hydrogen atom transfer (MHAT) followed by 1,2-radical acyloxy migration (1,2-RAM) to generate a tertiary carbon-centered radical at a site remote from the original alkene, affording protected tertiary alkyl amino alcohols across a broad substrate scope, with secondary variants also accessible. Experimental and computational studies support a C─N bond-forming step best described as radical ligand transfer (RLT) at a Co(III)─N intermediate, rather than Co(IV)/S

Indexed as

1,2‐radical acyloxy migrationhydroaminationmetal‐hydride hydrogen atom transferradical ligand transferremote‐Markovnikov

Identifiers

PMID42333929
PMCPMC13480516

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