ArticleClinical and translational science2026
EPHX2 Orchestrates Intestinal Epithelial Barrier Repair in Ulcerative Colitis: An Integrated Multi-Omics and Experimental Study.
Article in Clinical and translational science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
Genetic determinants are central to ulcerative colitis (UC) pathogenesis, yet their identification via single-cell transcriptomics and clinical translation remains incomplete. We integrated GWAS-eQTL data with UC-related differentially expressed genes (DEGs) to screen causal genes, mapped them in single-cell datasets, and prioritized Epoxide Hydrolase 2 (EPHX2) due to the key role of intestinal epithelial cells (IECs) in UC. Colitis mouse and in vitro inflammation models were used to validate EPHX2 expression. Gene Set Enrichment Analysis (GSEA) and functional assays explored its role in mechanisms such as wound healing. EPHX2, a causal gene expressed across epithelial subpopulations, was significantly downregulated in colitis models and cytokine-stimulated NCM460 cells. GSEA suggested its involvement in mucosal healing, and functional studies confirmed that EPHX2 deficiency impairs mucosal repair capacity. We propose that EPHX2 deficiency may compromise IEC-mediated mucosal healing in UC. This work advances the understanding of genetic determinants in UC and highlights a potential therapeutic target for disease management.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.