Trial reportJournal of gastroenterology and hepatology2026
The Efficacy of Pan-Indigo Carmine Chromoendoscopy by Water-Jet Pump in the Detection of Colorectal Lesions: A Randomized Controlled Trial.
Trial report in Journal of gastroenterology and hepatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06596317 (Impact of Indigo Carmine Pump Spraying on the Adenoma Detection Rate), which is not on this map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Impact of Indigo Carmine Pump Spraying on the Adenoma Detection Rate: A Randomized Controlled Trial
Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundPump-based chromoendoscopy is recommended for the surveillance of dysplasia associated with inflammatory bowel disease. This study was designed to compare the efficacy of pump-based pan chromoendoscopy (PCE) with white-light endoscopy (WLE) for the detection of colorectal neoplasia in patients at high risk of colorectal cancer (CRC).
methodThis randomized controlled trial prospectively recruited 366 participants who were randomly allocated in a 1:1 ratio to the WLE group and the PCE group. PRIMARY OUTCOME: adenoma detection rate (ADR); secondary outcome: mean number of adenomas per procedure (MAP), sessile serrated lesion detection rate (SDR), flat adenoma detection rate (FDR), and advanced adenoma detection rate (AADR).
resultThe ADR was significantly higher with PCE (86/167, 51.5%) versus WLE (57/165, 34.5%; RR 1.49 [95% 1.15 to 1.93]: p = 0.002). The FDR and SDR were significantly higher in PCE than in WLE (50.3% vs. 32.1% RR 1.57 [95% 1.20 to 2.05] p = 0.001; 10.8% vs. 2.4% RR 4.45 [95% CI 1.54 to 12.86] p = 0.002).
conclusionsThis study demonstrated that using a novel spraying technique with low-concentration indigo carmine during colonoscopy achieved a significantly higher detection rate for colorectal lesions. Moreover, PCE significantly increased ADR, particularly for flat adenomas and the detection rate of sessile serrated lesions.
trial registrationClinicalTrials.gov identifier: NCT06596317.
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