ArticleEndocrine, metabolic & immune disorders drug targets2026
Relationship between the Systemic Immune-Inflammation Index and Muscle Strength in Patients with Chronic Kidney Disease: A Cross-Sectional Study of Data from NHANES 2011-2014.
Article in Endocrine, metabolic & immune disorders drug targets, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThis study aimed to determine the relationship between Systemic Immune- Inflammation Index (SII) and muscle strength in patients with CKD.
methodsThis cross-sectional study examined adults with CKD using data from the National Health and Nutrition Examination Survey (2011-2014). The SII was calculated as: platelet count × neutrophil count/lymphocyte count. Muscle strength was determined from measurements of handgrip strength. Multivariate logistic regression and additional methods were used to assess the relationship between SII and muscle strength.
resultsWe examined 1620 patients with CKD (mean age: 61.4 years; 47% male). The overall prevalence of low muscle strength was 12.04%, and curve fitting indicated a positive, linear relationship between SII and low muscle strength. However, multivariate logistic regression analysis indicated that this relationship was not significant after adjustment for multiple confounders (odds ratio: 1.01, 95% CI: 0.99-1.02). These results were robust, and subgroup analyses showed no interactions. DISCUSSION: Inflammation, malnutrition, and chronic comorbidities can affect muscle metabolism in CKD patients. The relationship between SII and low muscle strength is complex and variable. Although SII reflects systemic immune activation, it is less capable than markers, such as IL-6 and CRP, in directly capturing tissue-level inflammation that leads to muscle atrophy.
conclusionThere was no significant association between SII and low muscle strength in patients with CKD, even after adjustment for nutritional status, comorbidities, and renal function. Although previous studies showed that CKD patients had increased inflammatory responses and decreased muscle strength, our results suggest underlying complexities may confound this relationship.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.