ArticlePain research & management2026
Acupuncture Alleviates Neuroinflammation in Chronic Migraine by Modulating Lactobacillus and Its Metabolite Pathways.
Article in Pain research & management, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Acupuncture Alleviates Neuroinflammation in Chronic Migraine by Modulating Lactobacillus and Its Metabolite Pathways.Pain research & management · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
backgroundChronic migraine (CM) is a highly prevalent and disabling neurological disorder lacking universally effective treatments. Acupuncture has shown significant clinical efficacy, yet its precise mechanisms remain unclear. This study aimed to evaluate the therapeutic effects and underlying mechanisms of acupuncture in CM, integrating gut microbiota and metabolomic analyses. MATERIALS AND
methodsForty-two Sprague-Dawley rats were randomly assigned to seven groups: control (Con), CM model (Mod), acupuncture (Acu), model + probiotics (Mod + Pro), model + antibiotics (Mod + Anti), acupuncture + probiotics (Acu + Pro), and acupuncture + antibiotics (Acu + Anti). CM was induced via subcutaneous nitroglycerin injection. Acupuncture was performed for nine days at bilateral Shuaigu (GB8) and Yanglingquan (GB34) points (20 min/day). Probiotics were administered by oral gavage of a mixed Lactobacillus preparation for 9 days; antibiotics were given as an oral cocktail for 2 weeks premodeling. Pain sensitivity and central inflammation were assessed by behavioral tests and ELISA. Gut microbiota and metabolites were profiled using 16S rDNA sequencing and metabolomics.
resultsAcupuncture alleviated pain hypersensitivity and central inflammation, reversing CM-induced gut dysbiosis, with marked effects on Akkermansia muciniphila and Lactobacillus. Metabolomics identified multiple altered metabolites, with strong correlations between Limosilactobacillus and unclassified_Lactobacillaceae and cis-5-dodecenoic acid and dihydrolipoamide. Network analysis revealed Limosilactobacillus as a core node, suggesting modulation of gut-brain axis signaling via specific metabolic pathways. Exogenous Lactobacillus markedly alleviated hyperalgesia and inflammation in model rats, with further analgesic and anti-inflammatory potentiation when combined with acupuncture.
conclusionAcupuncture may exert antimigraine effects by modulating the Lactobacillus-metabolite-inflammation axis, restoring gut homeostasis, and alleviating pain and neuroinflammation. Probiotic supplementation further supports the role of gut microbiota in mediating acupuncture's benefits, offering insight for mechanistic studies and clinical translation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.