ArticleJournal of the American Heart Association2026
Hypertensive Disorders of Pregnancy Associated With Cerebral Small Vessel Disease Decades Later.
Article in Journal of the American Heart Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
backgroundHypertensive disorders of pregnancy (HDP) are associated with elevated long-term risks of cerebrovascular disease. Emerging data suggest a link between HDP and dementia, potentially mediated by cerebral small vessel disease. We aimed to evaluate whether women with a history of HDP have more cerebral small vessel disease compared with women without HDP.
methodsThis retrospective cohort study included 1602 women from the Utah Population Database who underwent brain magnetic resonance imaging after their index pregnancy. Magnetic resonance imaging scans were evaluated for white matter hyperintensities, remote brain infarctions, cerebral microhemorrhages, enlarged perivascular spaces, acute infarction, and cerebral volume loss. Multivariable regression models assessed the association between HDP and imaging findings, adjusting for confounding factors. Interrater reliability was evaluated using Cohen's kappa.
resultsWomen with a history of HDP had higher white matter hyperintensities burden (adjusted mean difference, 0.57 [95% CI, 0.25-0.90];
conclusionsWomen with prior HDP show greater imaging evidence of cerebral microvascular injury decades after pregnancy, supporting HDP as a risk factor for later-life cerebrovascular health.
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