ArticleJournal of the American Heart Association2026
Endothelial Activation and Stress Index in Different Types of Hypertensive Pregnancy Disorders.
Article in Journal of the American Heart Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Association of the Endothelial Activation and Stress Index (EASIX) and the sFlt-1/PlGF Ratio in Patients with Preeclampsia.Diagnostics (Basel, Switzerland) · 2026Article
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10 authors.
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Abstract
backgroundEndothelial dysfunction is a major contributor to the pathophysiology of preeclampsia and can be quantified by the simple formula, lactate dehydrogenase×creatinine/thrombocytes, termed the Endothelial Activation and Stress Index (EASIX). We evaluated EASIX in hypertensive disorders of pregnancy and its value in the assessment of preeclampsia.
methodsThis retrospective study included 465 patients with preeclampsia, 197 with chronic or gestational hypertension, and 894 controls who delivered at Heidelberg University Hospital between 2017 and 2022. Propensity score matching was used to balance confounding variables. A total of 3732 EASIX values were available for the analysis.
resultsThe mean age was 31.8±5.6 years (preeclampsia), 32.9±5.3 years (hypertension), and 31.7±5.8 years (controls). EASIX was significantly higher in patients with preeclampsia as compared with patients with hypertension (0.94±0.58 versus 0.60±0.28,
conclusionsEASIX is a simple marker that could potentially discriminate patients with preeclampsia from healthy controls. We propose that EASIX may serve as a promising additional biomarker in the assessment of preeclampsia, prompting us to explore its incorporation in potential combined biomarker models in clinical routine.
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