ArticleJournal of the American Heart Association2026
Magnetic Resonance Imaging-Based Psoas Muscle Volume as an Additional Risk Factor for Fontan Failure: A Prospective Cohort Study.
Article in Journal of the American Heart Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundSarcopenia is prevalent in patients with Fontan circulation and may contribute to functional decline and adverse outcomes. It is commonly assessed using the cross-sectional area of the psoas muscle (PMA), although volumetric assessment of psoas muscle volume (PMV) may better capture true muscle mass. The ability of PMA versus PMV to differentiate patients with Fontan circulation from healthy controls and to provide incremental prognostic information remains incompletely defined.
methodsIn this prospective study, abdominopelvic magnetic resonance imaging was used to quantify PMA and PMV in 70 patients with Fontan circulation and 51 healthy controls with similar age and sex distribution. PMA at the fourth lumbar level and total PMV were indexed to body surface area. Group differences were assessed using nonparametric testing. Prognostic associations were evaluated using multivariable logistic regression.
resultsMale patients with Fontan circulation had lower PMV and PMA indexed to body surface area than healthy male patients (
conclusionsPMV indexed to body surface area may provide incremental prognostic information and serve as an adjunctive imaging biomarker of sarcopenia in Fontan circulation, although its independent predictive value for adverse outcomes requires further validation in larger cohorts.
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