ArticleScandinavian journal of primary health care2026
Association of insulin resistance and health-related quality of life with mild cognitive impairment during aging.
Article in Scandinavian journal of primary health care, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundPrevious studies have shown an association between dementia and diabetes. This study focused on examining whether insulin resistance is a risk factor for mild cognitive impairment (MCI). We also evaluated whether common cardiovascular risk factors or depressive symptoms modify the risk of MCI along with insulin resistance and compared the health-related quality of life (HRQoL) with or without MCI.
methodsThe participants were followed from 57 to 69 years of age and divided into two groups, MCI and non-MCI, according to their Consortium to Establish a Registry for Alzheimer's Disease
resultsGreater increases in HOMA-IR (OR 2.20, 95% CI 1.05-4.62) and fasting insulin (OR 3.49, 95% CI 1.48-8.23) increased the risk of MCI. Lower cognitive performance at baseline (OR 6.33; 95% CI 3.27-12.29), lower level of education (OR 3.94, 95% CI 1.76-8.81) and lower level of physical activity (OR 2.44, 95% CI 1.06-5.65) also increased the risk of MCI at follow-up. There was a greater decline in health-related quality of life among the MCI group.
conclusionInsulin resistance is a risk factor for MCI and MCI causes worsening of HRQoL during aging.
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