ArticleJournal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
Effectiveness of Multiple Platelet-Rich Plasma Injections for Olfactory Dysfunction.
Article in Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Validity and Reliability of the French Olfactory Disorders Questionnaire-10.Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-facialeArticle
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Authors and funding
2 authors.
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No grant is acknowledged in the PubMed record.
Abstract
ImportanceThe injections of platelet-rich plasma (PRP) in the olfactory clefts of patients with olfactory dysfunction (OD) is an emerging treatment. To date, no study investigated the effectiveness of multiple PRP injections.ObjectiveTo evaluate the effectiveness and usefulness of multiple injections of PRP in the olfactory clefts of patients with OD.DesignProspective controlled study.SettingMonocentric medical center.ParticipantsPatients with long-lasting OD treated with PRP injections and controls who underwent olfactory training with multiple psychophysical olfactory assessments.InterventionTwo PRP injections into the olfactory clefts at 4- to 6-month intervals.Main OutcomesOutcomes included adverse events, dose-effect relationships, and olfactory function changes measured by threshold, discrimination, and identification (TDI) testing with minimal clinically important difference (MCID).ResultsEighty-three subjects completed the evaluations. Patients had anosmia (n = 39), hyposmia (n = 27), and parosmia (n = 17). The mean duration of OD was 49.1 ± 46.9 months. Seventy-seven patients received 2 injections. Transient epistaxis was the primary adverse event (46.2%). The mean injected PRP volume ranged from 1.4 to 1.7 mL. TDI significantly increased after both first and second injections across all OD subgroups. MCID was achieved in 49.4% after a first injection and 28.9% after a second. MCID was reached in 63 cases (75.9%) from baseline to final evaluation. Baseline TDI strongly predicted post-second injection TDI (
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