ArticleRegenerative biomaterials2026
Comparative regenerative mechanisms of adipose-derived mesenchymal stem cell- and conditioned medium-loaded three-dimensional bioprinted hydrogels in chronic diabetic wounds.
Article in Regenerative biomaterials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Chronic diabetic wounds remain a major clinical challenge owing to impaired angiogenesis, persistent inflammation and cellular dysfunction. In this study, we developed a bioadhesive composite hydrogel scaffold (gelatin methacryloyl/alginate methacrylate [GA]) fabricated using digital light processing three-dimensional (3D) bioprinting, in which human adipose-derived mesenchymal stem cells (ADSCs) or their conditioned medium (CM) was incorporated to generate 3D skin constructs, and compared the paracrine effects on skin regeneration. We characterized the microstructures of GA-ADSC and GA-CM scaffolds; profiled CM proteins and systematically compared the effects of GA-ADSCs and GA-CM on fibroblast proliferation, migration, angiogenesis and macrophage polarization
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