Evidence map›Paper›PMID 42333376›Full record

ArticleInternational journal of chronic obstructive pulmonary disease2026

From China's Multicenter Prospective Cohort: Right Ventricular Afterload and Prognosis in Hospitalized Patients with Acute Exacerbation of COPD.

Aili Gao, Xia Liu, Xiaojing Jiao, Yuan Ding, Zehan Gao, Yuan Gao, Junwei Zhang, Junwei Yang, Suqiao Yang, Yuanhua Yang

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of chronic obstructive pulmonary disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Aili GaoDepartment of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020, People's Republic of China.ORCID 0000-0003-1247-1195
Xia LiuDepartment of Respiratory and Critical Care Medicine, Capital Medical University Daxing Teaching Hospital, Capital Medical University, Beijing, 102600, People's Republic of China.ORCID 0000-0002-2993-5905
Xiaojing JiaoDepartment of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020, People's Republic of China.
Yuan DingDepartment of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020, People's Republic of China.
Zehan GaoDepartment of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020, People's Republic of China.
Yuan GaoDepartment of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020, People's Republic of China.
Junwei ZhangDepartment of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020, People's Republic of China.
Junwei YangDepartment of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020, People's Republic of China.
Suqiao YangDepartment of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020, People's Republic of China.ORCID 0000-0001-7369-5999
Yuanhua YangDepartment of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: The relationship between increased right ventricular (RV) afterload (moderate-to-high suspicion of pulmonary hypertension indicated by echocardiography) and the prognosis of patients hospitalized with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is not yet well understood. Patients and Methods: This prospective cohort study was conducted in 11 hospitals from 2017 to 2020, involving patients hospitalized with AECOPD. Echocardiography was performed within 48 hours of admission. Patients were classified into two groups: those with increased RV afterload (n=237) and those with normal RV afterload (n=415). Hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated using Cox regression analysis to evaluate the impact of RV afterload on patient outcomes. Kaplan-Meier survival curves were employed to assess the association between RV afterload and 3-year all-cause mortality. Results: Kaplan-Meier survival curves demonstrated that the 3-year all-cause mortality rates were 22.8% in AECOPD patients with increased RV afterload and 9.5% in those with normal RV afterload. Cox regression analysis indicated that increased RV afterload is an independent predictor of poor prognosis in hospitalized AECOPD patients, significantly increasing the risk of 3-year all-cause mortality (HR=2.172, 95% CI: 1.384-3.411; Conclusion: Increased RV afterload is associated with a significant increase in the risk of 3-year all-cause mortality in patients hospitalized with AECOPD, posing a 2.2-fold higher risk compared to those with normal RV afterload. It also stands as an independent risk factor for mortality. Elevated BNP or NT-proBNP levels and reduced BMI are additional independent risk factors of mortality. Early detection of these three risk factors could play a role in stratifying high-risk patients, guiding clinical decision-making, and improving patient outcomes in AECOPD.

Indexed as

Pulmonary Disease, Chronic ObstructiveVentricular Dysfunction, RightVentricular Function, RightAgedChinaDisease ProgressionEchocardiographyFemaleHospitalizationHumansMaleMiddle AgedNatriuretic Peptide, BrainPeptide FragmentsPrognosisProspective StudiesNatriuretic Peptide, BrainPeptide Fragmentspro-brain natriuretic peptide (1-76)body mass indexechocardiographymortalityn-terminal pro-brain natriuretic peptide/brain natriuretic peptiderespiratory diseases

Identifiers

PMID42333376
PMCPMC13283401

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.