ArticleCureus2026
Targeted Therapy in Erdheim-Chester Disease: A Case Report and Review of the Literature.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Erdheim-Chester disease is a rare, aggressive non-Langerhans cell histiocytosis characterized by multisystem infiltration of histiocytes. It commonly affects middle-aged men and is driven by acquired mutations in the MAPK signaling pathway. This essential cellular pathway relays extracellular signals to the nucleus and regulates cell proliferation and survival. We report the case of a 39-year-old male who presented with progressive, severe left-sided frontal and temporal headaches. Imaging revealed a symptomatic craniocervical mass, a nonsecreting pituitary lesion, and bilateral perinephric soft tissue infiltration extending throughout the retroperitoneum. Histopathologic evaluation demonstrated foamy histiocytes consistent with Erdheim-Chester disease, and molecular testing identified a
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.