Evidence map›Paper›PMID 42333360›Full record

ReviewCureus2026

Oral-Systemic Links: A Narrative Review of the Role of Periodontitis in Alzheimer's Disease Development.

Nikolaos Spantidakis, Vasileios Zisis, Christina Charisi, Filippos Fytros, Konstantinos Poulopoulos, Thomas Chontos, Andreas Yiannouras, Petros Papadopoulos, Asterios Katsagkolis, Vasiliki Arsoudi and 3 more

Abstract readReview
In one paragraph

Review in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Nikolaos SpantidakisDentistry (Oral Medicine-Oral Pathology), European University Cyprus, Nicosia, CYP.
Vasileios ZisisDentistry (Oral Medicine-Oral Pathology), European University Cyprus, Nicosia, CYP.
Christina CharisiOral Medicine/Pathology, Aristotle University of Thessaloniki, Thessaloniki, GRC.
Filippos FytrosDentistry (Oral Medicine-Oral Pathology), European University Cyprus, Nicosia, CYP.
Konstantinos PoulopoulosDentoalveolar Surgery, Surgical Implantology and Radiology, Aristotle University of Thessaloniki, Thessaloniki, GRC.
Thomas ChontosFirst University Clinic of Ophthalmology, General Hospital of Athens "G. Gennimatas", Athens, GRC.
Andreas YiannourasDentistry (Oral Medicine-Oral Pathology), European University Cyprus, Nicosia, CYP.
Petros PapadopoulosOral Medicine/Pathology, Aristotle University of Thessaloniki, Thessaloniki, GRC.
Asterios KatsagkolisOral Medicine/Pathology, Aristotle University of Thessaloniki, Thessaloniki, GRC.
Vasiliki ArsoudiFirst University Clinic of Ophthalmology, General Hospital of Athens "G. Gennimatas", Athens, GRC.
Zoi Maria ThomaidiDentistry (Oral Medicine-Oral Pathology), European University Cyprus, Nicosia, CYP.
Athanasios PoulopoulosOral Medicine/Pathology, Aristotle University of Thessaloniki, Thessaloniki, GRC.
Smaragda DiamantiDentistry (Oral Medicine-Oral Pathology), European University Cyprus, Nicosia, CYP.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease (AD) and periodontitis are prevalent chronic conditions that disproportionately affect aging populations and pose substantial public health challenges worldwide. Increasing evidence suggests a potential association between these two diseases, with chronic oral infection and systemic inflammation emerging as key linking mechanisms. Periodontitis is characterized by a dysbiotic oral microbiome and persistent inflammatory responses that can lead to the dissemination of periodontal pathogens and their virulence factors into the systemic circulation. Notably, some studies have reported the detection of pathogens such as

Indexed as

alzheimer’s dementiaalzheimer’s-related diseasechronic generalized periodontitisoral-systemic connectionperiodontal status

Identifiers

PMID42333360
PMCPMC13283289

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.