ArticleCureus2026
Prolonged Invasive Mechanical Ventilation in a Tertiary Respiratory ICU: Outcomes, Challenges, and Future Directions.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background Prolonged invasive mechanical ventilation (PMV) represents a major challenge in critical care and is associated with high mortality, resource utilization, and long-term morbidity. Data from dedicated respiratory intensive care units (RICUs), particularly in resource-limited settings, remain limited. This study evaluates the clinical characteristics, management strategies, and outcomes of patients requiring PMV in a tertiary RICU. Methods This single-center observational case series included 40 consecutive patients requiring PMV, defined as >7 days of invasive mechanical ventilation, who were admitted to a tertiary RICU between January 2023 and March 2026. Data collected included demographics, primary diagnosis, comorbidities, APACHE II scores, microbiological profiles, ventilatory parameters, and outcomes. Standardized weaning protocols incorporating spontaneous breathing trials (SBTs), early tracheostomy, non-invasive ventilation (NIV) bridging, physiotherapy, and multidisciplinary care were applied. Successful weaning was defined as liberation from invasive ventilation without reintubation within 48 hours. Results The mean age was 66.5 years, with high illness severity reflected by a mean APACHE II score of 36.5. Common underlying conditions included severe pneumonia with acute respiratory distress syndrome, COPD/bronchiectasis overlap, and postoperative respiratory failure. Multidrug-resistant (MDR) Gram-negative infections, particularly
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