ArticleCureus2026
Planning-Based Dosimetric Comparison of Three-Dimensional Conformal Radiotherapy (Flattened Versus Unflattened Beams), Intensity-Modulated Radiotherapy, and Volumetric Modulated Arc Therapy for Pituitary Adenomas on Halcyon.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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0 citing papers in PubMed.
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study was undertaken to perform a dosimetric comparison of four distinct radiotherapy planning strategies for pituitary adenomas on the Varian Halcyon platform (Varian Medical Systems, Palo Alto, CA, USA): three-dimensional conformal radiotherapy (3DCRT) using electronically flattened beams, 3DCRT using true flattening filter-free (FFF) beams, intensity-modulated radiotherapy (IMRT), and volumetric modulated arc therapy (VMAT). The study additionally evaluated the feasibility and dosimetric implications of reproducing conventional forward-planned beam characteristics on an inherently FFF platform using dynamic multileaf collimator (MLC)-based electronic fluence shaping. Planning data from 15 patients were utilized. Four plans were generated per patient: 3DCRT with electronically flattened beams, 3DCRT with true FFF beams, IMRT, and VMAT. A prescription dose of 54 Gy in 30 fractions was applied with ≥95% planning target volume (PTV) coverage. Plan evaluation included D
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