ArticleCureus2026
Refractory Hypoxemia Secondary to Patent Foramen Ovale Presenting With Platypnea-Orthodeoxia Syndrome.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 author.
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Abstract
Patent foramen ovale (PFO) is a common congenital cardiac anomaly present in 20%-25% of adults and is usually clinically silent. In rare cases, it can result in significant right-to-left shunting and refractory hypoxemia, particularly in platypnea-orthodeoxia syndrome (POS). We describe a 59-year-old woman with chronic hypoxemic respiratory failure who developed worsening oxygenation despite high-flow supplemental oxygen. Comprehensive evaluation excluded primary pulmonary, vascular, and parenchymal etiologies. Contrast echocardiography demonstrated a PFO with early right-to-left shunting. Percutaneous closure resulted in immediate and sustained improvement in oxygenation, with liberation from supplemental oxygen.
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