ArticleFEBS open bio2026
A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress.
Article in FEBS open bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
We present a novel miniaturized flow chip platform enabling thin-layer smooth muscle cell (SMC) culture, continuous tangential perfusion, dual-channel nutrient control, and longitudinal subcellular resolution 3-D imaging via multiphoton microscopy. Using a case study of longitudinal imaging of vascular calcification, a key pathological process in cardiovascular disease typically challenging to dynamically model under physiological flow, we describe the platform and its potential. Within this system, immortalized vascular SMCs embedded in fibrin hydrogel on a textile-reinforced scaffold are exposed to unidirectional flow (12 mL·min
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