Evidence map›Paper›PMID 42332857›Full record

ArticleMacromolecular rapid communications2026

Biocompatible Sulfobetaine Polymer-Artemisinin Conjugates Inducing Ferroptosis in Cancer Cells: Synthesis by Mechanochemical Solid-State Polymerization and Characterization.

Naoki Doi, Yukinori Yamauchi, Yasushi Sasai, Ryosuke Nagai, Ayaka Koike, Madoka Ikawa, Toru Yoshimoto, Satoshi Yamada, Masayuki Kuzuya, Shin-Ichi Kondo

Abstract read
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In one paragraph

Article in Macromolecular rapid communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Naoki DoiLaboratory of Pharmaceutical Physical Chemistry, Gifu Pharmaceutical University, Gifu, Japan.ORCID https://orcid.org/0000-0002-9773-1429
Yukinori YamauchiDepartment of Pharmaceutical Physical Chemistry, College of Pharmaceutical Sciences, Matsuyama University, Matsuyama, Ehime, Japan.
Yasushi SasaiFaculty of Pharmacy, Gifu University of Medical Science, Gifu, Japan.
Ryosuke NagaiLaboratory of Pharmaceutical Physical Chemistry, Gifu Pharmaceutical University, Gifu, Japan.
Ayaka KoikeLaboratory of Pharmaceutical Physical Chemistry, Gifu Pharmaceutical University, Gifu, Japan.
Madoka IkawaLaboratory of Pharmaceutical Physical Chemistry, Gifu Pharmaceutical University, Gifu, Japan.
Toru YoshimotoLaboratory of Pharmaceutical Physical Chemistry, Gifu Pharmaceutical University, Gifu, Japan.
Satoshi YamadaLaboratory of Pharmaceutical Physical Chemistry, Gifu Pharmaceutical University, Gifu, Japan.
Masayuki KuzuyaLaboratory of Pharmaceutical Physical Chemistry, Gifu Pharmaceutical University, Gifu, Japan.
Shin-Ichi KondoLaboratory of Pharmaceutical Physical Chemistry, Gifu Pharmaceutical University, Gifu, Japan.ORCID https://orcid.org/0000-0003-4222-0004

Funding

Izumi Science and Technology FoundationJSPS KAKENHI 25K09926Takeda Science FoundationUehara Memorial Foundation
6 · The paper itself

Abstract

Artemisinin derivatives (ARTs) induce ferrous iron-dependent cell death (ferroptosis) by generating free radicals. Since the concentration of ferrous ions within cancer cells is high, the specific delivery of ARTs into cancer cells is advantageous for cancer therapy. Herein, we fabricate the biocompatible sulfobetaine polymer-ARTs conjugates through the mechanochemical solid-state copolymerization of sulfobetaine methacrylate (SBMA) and ARTs-conjugated monomer. A polymer conversion rate of more than 90% is achieved within 60 min of copolymerization. The number average molecular weight and heterogeneity of resulting water-soluble PSBMA-ARTs conjugates are 8,000 g mol

Indexed as

Antineoplastic AgentsArtemisininsBetaineBiocompatible MaterialsFerroptosisPolymersCell Line, TumorCell SurvivalDrug Screening Assays, AntitumorHumansMethacrylatesMolecular StructurePolymerizationAntineoplastic AgentsartemisininArtemisininsBetaineBiocompatible MaterialsMethacrylatesPolymerssulfobetaineartemisinindrug delivery systemferroptosismechanochemical solid‐state polymerizationpolymer‐drug conjugatessulfobetaine polymer

Identifiers

PMID42332857
PMCPMC13435009

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.