Evidence map›Paper›PMID 42332796›Full record

ArticleBMC pharmacology & toxicology2026

Pregabalin enhances the proliferative potential of pancreatic cancer in vitro but not in mice with pancreatic cancer.

Tomoaki Itaya, Makoto Sano, Ichie Kajiwara, Yukino Oshima, Tomoya Kuramochi, Jinsuk Kim, Osamu Kitajima, Hideaki Ijichi, Takahiro Suzuki

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In one paragraph

Article in BMC pharmacology & toxicology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Tomoaki ItayaDepartment of Anesthesiology Nihon University School of Medicine, Itabashi-ku, Tokyo, Japan. itaya.tomoaki@nihon-u.ac.jp.ORCID https://orcid.org/0000-0001-9679-9395
Makoto SanoDepartment of Anesthesiology Nihon University School of Medicine, Itabashi-ku, Tokyo, Japan.
Ichie KajiwaraDepartment of Anesthesiology Nihon University School of Medicine, Itabashi-ku, Tokyo, Japan.
Yukino OshimaDepartment of Anesthesiology Nihon University School of Medicine, Itabashi-ku, Tokyo, Japan.
Tomoya KuramochiDepartment of Obstetrics and Gynecology, Juntendo University, Urayasu Hospital, Urayasu, Chiba, Japan.
Jinsuk KimDepartment of Anesthesiology Nihon University School of Medicine, Itabashi-ku, Tokyo, Japan.
Osamu KitajimaDepartment of Anesthesiology Nihon University School of Medicine, Itabashi-ku, Tokyo, Japan.
Hideaki IjichiDepartment of Gastroenterology Graduate School of Medicine, The University of Tokyo, Hongo, Tokyo, Japan.
Takahiro SuzukiDepartment of Anesthesiology Nihon University School of Medicine, Itabashi-ku, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe previously reported that mirogabalin, a selective voltage-gated calcium channel α2δ1/α2δ2 ligand, increases the proliferative potential of pancreatic cancer. However, the risk of pregabalin, a non-selective α2δ ligand, is unknown in pancreatic cancer. Therefore, the proliferation of murine pancreatic cancer cell lines was studied following treatment with pregabalin.

methodsSix-week-old pancreatic cancer mouse model KPPC (LSL-Kras

resultsThe number of pancreatic cancer cells were increased by 100 and 300 μM pregabalin in vitro. The pain scores in KPPC mice were decreased by pregabalin, but there was no significant difference in the survival rate or tumor size. Interestingly, pregabalin increased the local infiltration of CD8

conclusionsThese findings suggest that pregabalin increases the proliferative ability of pancreatic cancer cells in vitro without promoting tumor growth in vivo. Additionally, it induces an alteration with an increase in tumor-infiltrating lymphocytes and dendritic cells, along with a decrease in M2-like tumor-associated macrophages and cancer-associated fibroblasts in vivo.

Indexed as

AnalgesicsCarcinoma, Pancreatic DuctalPancreatic NeoplasmsPregabalinAnimalsCell Line, TumorCell ProliferationCytokinesMaleMiceMice, Inbred C57BLAnalgesicsCytokinesPregabalinCancer-associated painCancer-stromal interactionGabapentinPancreatic ductal adenocarcinomaPregabalin

Identifiers

PMID42332796
PMCPMC13540837

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.