Evidence map›Paper›PMID 42332793›Full record

ReviewCell & bioscience2026

Cellular prion protein and its derived peptides: multifaceted roles in neurodegenerative diseases and potential as biomarkers.

Emanuela Mari, Michele Aventaggiato, Emanuela Paldino, Simona Ceccarelli, Nicola Mucci, Giovanni Bellomo, Elisabetta Mantuano, Stefano Dugheri, Stefano Martellucci, Vincenzo Mattei

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cell & bioscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Emanuela MariDepartment of Life Sciences, Health, and Health Professions, Link Campus University, Rome, Italy.
Michele AventaggiatoDepartment of Life Sciences, Health, and Health Professions, Link Campus University, Rome, Italy.
Emanuela PaldinoDepartment of Life Sciences, Health, and Health Professions, Link Campus University, Rome, Italy.
Simona CeccarelliDepartment of Experimental Medicine, Sapienza University, Rome, Italy.
Nicola MucciDepartment of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
Giovanni BellomoDepartment of Life Sciences, Health, and Health Professions, Link Campus University, Rome, Italy.
Elisabetta MantuanoDepartment of Life Sciences, Health, and Health Professions, Link Campus University, Rome, Italy.
Stefano DugheriDepartment of Life Sciences, Health, and Health Professions, Link Campus University, Rome, Italy.
Stefano MartellucciDepartment of Life Sciences, Health, and Health Professions, Link Campus University, Rome, Italy. s.martellucci@unilink.it.ORCID https://orcid.org/0000-0002-3952-3162
Vincenzo MatteiDepartment of Life Sciences, Health, and Health Professions, Link Campus University, Rome, Italy. v.mattei@unilink.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and transmissible spongiform encephalopathies (TSEs), share fundamental mechanisms of protein misfolding, synaptic dysfunction, and progressive neuronal loss. The cellular prion protein (PrP

Indexed as

BiomarkersCellular prion proteinNeurodegenerative diseasesPrion protein fragments

Identifiers

PMID42332793
PMCPMC13536720

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.