Evidence map›Paper›PMID 42332741›Full record

ArticleBMC pulmonary medicine2026

Clinical study of bronchial wall area proportion in children and adolescents based on CT images.

Leitao Wen, Cong Shen, Yuedong Han, Xiu'e Wang

Abstract read
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Article in BMC pulmonary medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Leitao WenImaging Center, Xi'An Gaoxin Hospital, 16 Tuanjie South Road, Yanta District, Xi'An, Shanxi Province, 710075, China.
Cong ShenImaging Center, the First Affiliated Hospital of Xi'An Jiaotong University, Xi'An, Shanxi Province, 710061, China.
Yuedong HanImaging Center, Xi'An Gaoxin Hospital, 16 Tuanjie South Road, Yanta District, Xi'An, Shanxi Province, 710075, China.
Xiu'e WangImaging Center, Xi'An Gaoxin Hospital, 16 Tuanjie South Road, Yanta District, Xi'An, Shanxi Province, 710075, China. xiue-w@ldy.edu.rs.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study aims to elucidate the distribution and characteristics of bronchial wall area proportion (WA%), defined as [average wall area / (average wall area + average lumen area)], in the lungs of healthy Chinese children and adolescents aged 0-18 years.

methodsIn this cross-sectional retrospective study, chest CT scans from 795 healthy children and adolescents (482 males [61%], 313 females [39%]) aged 0-18 years were analyzed. Participants were stratified into 19 age-specific groups based on sex. Bronchial structures were automatically identified and quantified using a digital pulmonary tracheal branch measurement tool, enabling comprehensive assessment of WA% across all lung segments in the study population.

resultsWA% showed a negative correlation with age in bronchial generations beyond the second airway branch across the pediatric population. This trend was more pronounced in males than females. No significant sex differences in WA% were observed across most age groups (0-15 years, P > 0.05). However, significant differences emerged from age 16 onward in the trachea (generation 0), lung lobes, and upper bronchi (generations 1-2/3), with males consistently exhibiting lower WA% values compared to females (P < 0.05).

conclusionIn children and adolescents aged 0-18 years, bronchial WA% decreases with age. From age 16 onward, sex differences become evident, with males showing lower WA% in the trachea, lung lobes, and upper bronchi compared to females. These findings provide baseline reference data for bronchial wall characteristics in healthy pediatric populations.

Indexed as

BronchiLungTomography, X-Ray ComputedAdolescentAge FactorsChildChild, PreschoolChinaCross-Sectional StudiesFemaleHumansInfantInfant, NewbornMaleRetrospective StudiesSex FactorsAutomatic measurementBronchial WA%Normal chest CTNormal children and adolescents

Identifiers

PMID42332741
PMCPMC13540811

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