Evidence map›Paper›PMID 42332549›Full record

ArticleCellular & molecular biology letters2026

IL17 signaling promotes oocyte developmental competence acquisition during maturation.

Huaxing Zhao, Xiaohua He, Junsong Shi, Xiao Wu, Yalin Liang, Xingwang Wang, Zheng Ao, Xianjun Zhang, Yuxing Zhang, Yanan Li and 15 more

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Article in Cellular & molecular biology letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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25 authors.

Huaxing Zhao *Guangdong Laboratory for Lingnan Modern Agriculture, National Engineering Research Center for Breeding Swine Industry, State Key Laboratory of Swine and Poultry Breeding Industry, National and Local Joint Engineering Research Center for Livestock and Poultry Breeding Industry, Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, Gene Bank of Guangdong Local Livestock and Poultry, College of Animal Science, South China Agricultural University, Guangzhou, Guangdong, China.
Xiaohua He *Guangdong Laboratory for Lingnan Modern Agriculture, National Engineering Research Center for Breeding Swine Industry, State Key Laboratory of Swine and Poultry Breeding Industry, National and Local Joint Engineering Research Center for Livestock and Poultry Breeding Industry, Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, Gene Bank of Guangdong Local Livestock and Poultry, College of Animal Science, South China Agricultural University, Guangzhou, Guangdong, China.
Junsong Shi *Yunfu Branch of Guangdong Provincial Laboratory of Lingnan Modern Agricultural Science and Technology, Guangdong Zhongxin Breeding Technology Co., Ltd., Yunfu, Guangdong, China.
Xiao WuGuangdong Laboratory for Lingnan Modern Agriculture, National Engineering Research Center for Breeding Swine Industry, State Key Laboratory of Swine and Poultry Breeding Industry, National and Local Joint Engineering Research Center for Livestock and Poultry Breeding Industry, Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, Gene Bank of Guangdong Local Livestock and Poultry, College of Animal Science, South China Agricultural University, Guangzhou, Guangdong, China.
Yalin LiangGuangdong Laboratory for Lingnan Modern Agriculture, National Engineering Research Center for Breeding Swine Industry, State Key Laboratory of Swine and Poultry Breeding Industry, National and Local Joint Engineering Research Center for Livestock and Poultry Breeding Industry, Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, Gene Bank of Guangdong Local Livestock and Poultry, College of Animal Science, South China Agricultural University, Guangzhou, Guangdong, China.
Xingwang WangGuangdong Laboratory for Lingnan Modern Agriculture, National Engineering Research Center for Breeding Swine Industry, State Key Laboratory of Swine and Poultry Breeding Industry, National and Local Joint Engineering Research Center for Livestock and Poultry Breeding Industry, Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, Gene Bank of Guangdong Local Livestock and Poultry, College of Animal Science, South China Agricultural University, Guangzhou, Guangdong, China.
Zheng AoKey Laboratory of Animal Genetics, Breeding and Reproduction in the Plateau Mountainous Region, Ministry of Education, College of Animal Science, Guizhou University, Guiyang, Guizhou, China.
Xianjun ZhangGuangdong Laboratory for Lingnan Modern Agriculture, National Engineering Research Center for Breeding Swine Industry, State Key Laboratory of Swine and Poultry Breeding Industry, National and Local Joint Engineering Research Center for Livestock and Poultry Breeding Industry, Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, Gene Bank of Guangdong Local Livestock and Poultry, College of Animal Science, South China Agricultural University, Guangzhou, Guangdong, China.
Yuxing ZhangGuangdong Laboratory for Lingnan Modern Agriculture, National Engineering Research Center for Breeding Swine Industry, State Key Laboratory of Swine and Poultry Breeding Industry, National and Local Joint Engineering Research Center for Livestock and Poultry Breeding Industry, Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, Gene Bank of Guangdong Local Livestock and Poultry, College of Animal Science, South China Agricultural University, Guangzhou, Guangdong, China.
Yanan LiGuangdong Laboratory for Lingnan Modern Agriculture, National Engineering Research Center for Breeding Swine Industry, State Key Laboratory of Swine and Poultry Breeding Industry, National and Local Joint Engineering Research Center for Livestock and Poultry Breeding Industry, Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, Gene Bank of Guangdong Local Livestock and Poultry, College of Animal Science, South China Agricultural University, Guangzhou, Guangdong, China.
Yiqian ZhangGuangdong Laboratory for Lingnan Modern Agriculture, National Engineering Research Center for Breeding Swine Industry, State Key Laboratory of Swine and Poultry Breeding Industry, National and Local Joint Engineering Research Center for Livestock and Poultry Breeding Industry, Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, Gene Bank of Guangdong Local Livestock and Poultry, College of Animal Science, South China Agricultural University, Guangzhou, Guangdong, China.
Yazheng DongGuangdong Laboratory for Lingnan Modern Agriculture, National Engineering Research Center for Breeding Swine Industry, State Key Laboratory of Swine and Poultry Breeding Industry, National and Local Joint Engineering Research Center for Livestock and Poultry Breeding Industry, Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, Gene Bank of Guangdong Local Livestock and Poultry, College of Animal Science, South China Agricultural University, Guangzhou, Guangdong, China.
Jingfeng PengGuangdong Laboratory for Lingnan Modern Agriculture, National Engineering Research Center for Breeding Swine Industry, State Key Laboratory of Swine and Poultry Breeding Industry, National and Local Joint Engineering Research Center for Livestock and Poultry Breeding Industry, Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, Gene Bank of Guangdong Local Livestock and Poultry, College of Animal Science, South China Agricultural University, Guangzhou, Guangdong, China.
Yunfei HouGuangdong Laboratory for Lingnan Modern Agriculture, National Engineering Research Center for Breeding Swine Industry, State Key Laboratory of Swine and Poultry Breeding Industry, National and Local Joint Engineering Research Center for Livestock and Poultry Breeding Industry, Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, Gene Bank of Guangdong Local Livestock and Poultry, College of Animal Science, South China Agricultural University, Guangzhou, Guangdong, China.
Rong ZhouYunfu Branch of Guangdong Provincial Laboratory of Lingnan Modern Agricultural Science and Technology, Guangdong Zhongxin Breeding Technology Co., Ltd., Yunfu, Guangdong, China.
Fang ZengCollege of Marine Science, South China Agricultural University, Guangzhou, Guangdong, China.
Linjun HongGuangdong Laboratory for Lingnan Modern Agriculture, National Engineering Research Center for Breeding Swine Industry, State Key Laboratory of Swine and Poultry Breeding Industry, National and Local Joint Engineering Research Center for Livestock and Poultry Breeding Industry, Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, Gene Bank of Guangdong Local Livestock and Poultry, College of Animal Science, South China Agricultural University, Guangzhou, Guangdong, China.
Ting GuGuangdong Laboratory for Lingnan Modern Agriculture, National Engineering Research Center for Breeding Swine Industry, State Key Laboratory of Swine and Poultry Breeding Industry, National and Local Joint Engineering Research Center for Livestock and Poultry Breeding Industry, Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, Gene Bank of Guangdong Local Livestock and Poultry, College of Animal Science, South China Agricultural University, Guangzhou, Guangdong, China.
Huaqiang YangGuangdong Laboratory for Lingnan Modern Agriculture, National Engineering Research Center for Breeding Swine Industry, State Key Laboratory of Swine and Poultry Breeding Industry, National and Local Joint Engineering Research Center for Livestock and Poultry Breeding Industry, Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, Gene Bank of Guangdong Local Livestock and Poultry, College of Animal Science, South China Agricultural University, Guangzhou, Guangdong, China.
Jie YangGuangdong Laboratory for Lingnan Modern Agriculture, National Engineering Research Center for Breeding Swine Industry, State Key Laboratory of Swine and Poultry Breeding Industry, National and Local Joint Engineering Research Center for Livestock and Poultry Breeding Industry, Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, Gene Bank of Guangdong Local Livestock and Poultry, College of Animal Science, South China Agricultural University, Guangzhou, Guangdong, China.
Zheng XuGuangdong Laboratory for Lingnan Modern Agriculture, National Engineering Research Center for Breeding Swine Industry, State Key Laboratory of Swine and Poultry Breeding Industry, National and Local Joint Engineering Research Center for Livestock and Poultry Breeding Industry, Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, Gene Bank of Guangdong Local Livestock and Poultry, College of Animal Science, South China Agricultural University, Guangzhou, Guangdong, China.
Sixiu HuangGuangdong Laboratory for Lingnan Modern Agriculture, National Engineering Research Center for Breeding Swine Industry, State Key Laboratory of Swine and Poultry Breeding Industry, National and Local Joint Engineering Research Center for Livestock and Poultry Breeding Industry, Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, Gene Bank of Guangdong Local Livestock and Poultry, College of Animal Science, South China Agricultural University, Guangzhou, Guangdong, China.
Gengyuan CaiGuangdong Laboratory for Lingnan Modern Agriculture, National Engineering Research Center for Breeding Swine Industry, State Key Laboratory of Swine and Poultry Breeding Industry, National and Local Joint Engineering Research Center for Livestock and Poultry Breeding Industry, Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, Gene Bank of Guangdong Local Livestock and Poultry, College of Animal Science, South China Agricultural University, Guangzhou, Guangdong, China.
Zicong LiGuangdong Laboratory for Lingnan Modern Agriculture, National Engineering Research Center for Breeding Swine Industry, State Key Laboratory of Swine and Poultry Breeding Industry, National and Local Joint Engineering Research Center for Livestock and Poultry Breeding Industry, Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, Gene Bank of Guangdong Local Livestock and Poultry, College of Animal Science, South China Agricultural University, Guangzhou, Guangdong, China. lizicong@scau.edu.cn.
Zhenfang WuGuangdong Laboratory for Lingnan Modern Agriculture, National Engineering Research Center for Breeding Swine Industry, State Key Laboratory of Swine and Poultry Breeding Industry, National and Local Joint Engineering Research Center for Livestock and Poultry Breeding Industry, Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, Gene Bank of Guangdong Local Livestock and Poultry, College of Animal Science, South China Agricultural University, Guangzhou, Guangdong, China. wzf@scau.edu.cn.

Funding

Department of Agriculture and Rural Affairs of Guangdong Province, China 2024-XPY-00-004Double first-class discipline promotion project 2023B10564001
6 · The paper itself

Abstract

backgroundDefects in the acquisition of oocyte developmental competence during the maturation process causes subfertility or infertility in animals and humans. Understanding the regulatory mechanisms of oocyte maturation is essential for reproductive biology and medicine. Follicular fluid (FF) is an important microenvironment governing oocyte maturation.

methodsA tandem mass tags (TMT)-based comparative FF proteomic analysis was employed to identify FF proteins that are potentially crucial for oocyte maturation. A very large number of pig and mouse oocytes (approximately 20,000) and embryos (over 13,000, including somatic cell nuclear transfer, parthenogenetic activation, and in vitro fertilization embryos) were used to investigate the effects of identified FF proteins on in vitro oocyte maturation and subsequent in vitro and in vivo embryo development. RNA sequencing, quantitative PCR, enzyme-linked immunosorbent assays, and immunofluorescence were used to study the expression patterns and action mechanisms of identified FF proteins in oocytes. In addition, intra-oocyte levels of glutathione and reactive oxygen species were measured to assess redox homeostasis.

resultsInterleukin 17D (IL17D) was identified as an important FF protein and it is significantly upregulated in porcine FF during oocyte maturation. IL17D promotes oocyte maturation by enhancing bidirectional communication between oocytes and cumulus cells, via upregulating CX43 expression and transzonal projections, which helps to maintain oocyte redox homeostasis and nuclear-cytoplasmic synchrony. IL17D treatment of oocytes enhances subsequent in vitro and in vivo full-term embryo development by modulating lipid metabolism and histone modification reprogramming. IL17D exerts its function via activating IL17 signaling through binding to CD93. Two other IL17 family members, IL17A and IL17F, also enhance oocyte maturation quality. IL17D displays a conserved expression pattern and function in pig and mouse oocytes.

conclusionsThis study reveals the critical roles of IL17D in regulating oocyte developmental competence acquisition during maturation by activating IL17 signaling. The findings provide valuable insights into the molecular mechanisms underlining oocyte developmental potential acquisition and may help to develop methods for efficient production of oocytes for assisted reproduction.

Indexed as

Interleukin-17OocytesOogenesisSignal TransductionAnimalsCumulus CellsEmbryonic DevelopmentFemaleFollicular FluidMiceReactive Oxygen SpeciesSwineInterleukin-17Reactive Oxygen SpeciesCell communicationFollicular fluidIL17DIL17 signalingOocyteProteome

Identifiers

PMID42332549
PMCPMC13560242

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