Evidence map›Paper›PMID 42332350›Full record

ArticleZhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences2026

[Methyltransferase-like protein 7B promotes glycolysis and malignant progression in papillary thyroid carcinoma cells via the USP28/HIF-1α axis].

Fengyu Xu, Qiuping Xie

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

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4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

2 authors.

Fengyu XuDepartment of Thyroid Surgery, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China. drxu@zju.edu.cn.
Qiuping XieDepartment of Thyroid Surgery, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China. yushengxqp@zju.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo investigate the expression of methyltransferase-like protein 7B (METTL7B) in papillary thyroid carcinoma (PTC) and elucidate its role and molecular mechanisms in tumor metabolic reprogramming and malignant progression.

methodsPublic datasets from Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) were used to analyze METTL7B expression in PTC and its association with clinicopathological features. Immunohistochemistry on tissue microarrays was performed to validate METTL7B protein expression in clinical samples. Stable

resultsMETTL7B was significantly upregulated in PTC tissues (

conclusionsMETTL7B promotes glycolysis and malignant progression in PTC cells by stabilizing HIF-1α through USP28-mediated deubiquitination.

Indexed as

GlycolysisHypoxia-Inducible Factor 1, alpha SubunitMethyltransferasesThyroid Cancer, PapillaryThyroid NeoplasmsAnimalsCell Line, TumorCell ProliferationDisease ProgressionFemaleGene Expression Regulation, NeoplasticHumansMaleMiceMice, NudeSignal TransductionHIF1A protein, humanHypoxia-Inducible Factor 1, alpha SubunitMethyltransferasesGlycolysisHypoxia-inducible factor-1αMethyltransferase-like protein 7BNude micePapillary thyroid carcinomaUbiquitin-specific protease 28

Identifiers

PMID42332350
PMCPMC13388235

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.