ArticleCanadian journal of anaesthesia = Journal canadien d'anesthesie2026
Association between lactate clearance rate and 28-day mortality in patients with sepsis: a retrospective cohort study and exploration of an optimal lactate clearance as an endpoint of resuscitation.
Article in Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeIn this study, we sought to investigate the relationship between lactate clearance rate per hour (LCR
methodsWe conducted a retrospective analysis using the Medical Information Mart for Intensive Care IV (MIMIC-IV) and eICU databases (eICU Collaborative Research Database), including patients with sepsis with a peak lactate level (Lac
resultsWe retrospectively analyzed data from 53,150 patients from the MIMIC-IV database and 55,887 patients from the eICU database; of these, 13,586 patients with sepsis met the inclusion criteria. Among these, 3,313 (24.4%) patients died within 28 days. Multivariable logistic regression showed that a higher LCR
conclusionsIn patients with sepsis, the relationship between lactate clearance during resuscitation and 28-day mortality was nonlinear. The mortality rate declined steeply with increasing lactate clearance until a point was reached, after which the survival benefit plateaued. These findings provide new insights for clinicians in defining individualized endpoints for fluid resuscitation in sepsis management.
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