Evidence map›Paper›PMID 42332289›Full record

ReviewNature reviews. Microbiology2026

Klebsiella genus as driver of human disease: from infections to non-communicable disorders.

Serena Porcari, Margherita Ferrari, Anna Melekhova, Andrea Severino, William Fusco, Aurora Sveva Carlà, Flavio De Maio, Herbert Tilg, Antonio Gasbarrini, Eran Elinav and 1 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Serena Porcari *Department of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, Rome, Italy.
Margherita Ferrari *Department of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, Rome, Italy.ORCID http://orcid.org/0009-0001-8909-0107
Anna Melekhova *Department of Systems Immunology, Weizmann Institute of Science, Rehovot, Israel.
Andrea SeverinoDepartment of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, Rome, Italy.
William FuscoDepartment of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, Rome, Italy.
Aurora Sveva CarlàDepartment of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, Rome, Italy.
Flavio De MaioDepartment of Laboratory and Hematology Sciences, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Herbert TilgDepartment of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology and Metabolism, Medical University Innsbruck, Innsbruck, Austria.ORCID http://orcid.org/0000-0002-4235-2579
Antonio GasbarriniDepartment of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, Rome, Italy.
Eran ElinavDepartment of Systems Immunology, Weizmann Institute of Science, Rehovot, Israel.ORCID http://orcid.org/0000-0002-5775-2110
Gianluca IaniroDepartment of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, Rome, Italy. gianluca.ianiro@unicatt.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Klebsiella spp. are pathobionts associated with acute infections, including pneumonia and infections in the urinary tract and bloodstream, often acquired in health-care settings. They represent a global threat owing to the prevalence of multidrug-resistant strains. Moreover, Klebsiella spp., similarly to other members of the human gut microbiota, can contribute to the pathogenesis of non-communicable disorders. In this Review, we describe the taxonomical and molecular characteristics of the Klebsiella genus, as well as its epidemiology and impact as an infectious agent. We also review current evidence that associates Klebsiella spp. with different non-communicable disorders, including chronic inflammatory and metabolic disorders and cancer. We discuss different approaches to target Klebsiella spp., including tailored antibiotics, faecal microbiota transplantation, live biotherapeutic products and bacteriophages. Finally, we discuss the importance of preventative measures, such as epidemiological surveillance, infection control practices and lifestyle interventions, to reduce the spread of Klebsiella spp. in health-care settings and the broader community.

Indexed as

KlebsiellaKlebsiella InfectionsNoncommunicable DiseasesAnti-Bacterial AgentsFecal Microbiota TransplantationHumansNeoplasmsAnti-Bacterial Agents

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.