Evidence map›Paper›PMID 42332281›Full record

ArticleNeurocritical care2026

Determinants of Brain Tissue Normoxia in Patients with Large Spontaneous Intracerebral Hemorrhage.

Anna Berek, Philipp Kindl, Bogdan Ianosi, Max Gaasch, Mario Kofler, Melanie Bergmann, Lauma Putnina, Raimund Helbok, Alois J Schiefecker, Bettina Pfausler and 2 more

Abstract read
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In one paragraph

Article in Neurocritical care, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Anna BerekNeurological Intensive Care Unit, Department of Neurology, Medical University of Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria.
Philipp KindlNeurological Intensive Care Unit, Department of Neurology, Medical University of Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria.
Bogdan IanosiDepartment of Neurology, Kepler University Hospital, Johannes Kepler University Linz, Linz, Austria.
Max GaaschNeurological Intensive Care Unit, Department of Neurology, Medical University of Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria.
Mario KoflerDepartment of Anaesthesiology and Intensive Care Medicine, Medical University of Innsbruck, Innsbruck, Austria.
Melanie BergmannDepartment of Anaesthesiology and Intensive Care Medicine, Medical University of Innsbruck, Innsbruck, Austria.
Lauma PutninaDepartment of Anaesthesiology and Intensive Care Medicine, Medical University of Innsbruck, Innsbruck, Austria.
Raimund HelbokDepartment of Neurology, Kepler University Hospital, Johannes Kepler University Linz, Linz, Austria.
Alois J SchiefeckerNeurological Intensive Care Unit, Department of Neurology, Medical University of Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria.
Bettina PfauslerNeurological Intensive Care Unit, Department of Neurology, Medical University of Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria.
Ronny BeerNeurological Intensive Care Unit, Department of Neurology, Medical University of Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria.
Verena RassNeurological Intensive Care Unit, Department of Neurology, Medical University of Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria. verena.rass@tirol-kliniken.at.ORCID http://orcid.org/0000-0002-4241-5891

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectivesThe prevalence of brain tissue hypoxia (BTH; P

methodsThis retrospective cohort study included 58 patients with ICH admitted to a neurological intensive care unit (ICU) between 2010 and 2020 with multimodal invasive neuromonitoring. BTN was sought by avoiding low cerebral perfusion pressure (CPP) and low blood hemoglobin levels, and by maintaining normocapnia, normoxemia, normothermia, and metabolic homeostasis. Hourly P

resultsPatients were 61 [interquartile range (IQR), 55-69] years old and presented with an ICH score of 2 (1-3). Of the patients, 52 (90%) underwent surgical evacuation via hemicraniectomy and/or craniotomy, while 6 (10%) received invasive neuromonitoring only. The median initial ICH volume was 40.2 (IQR 29.5-55.8) mL. Surgical evacuation achieved a median reduction of 86.6% (IQR 69.0-94.2), leaving a median residual volume of 5.5 (IQR 3.0-14.1) mL. The overall prevalence of BTH was 31%. In multivariable analysis, the following factors led to the highest percentage of BTN: CPP 80-89 mm Hg [odds ratio (OR) 1.88, 95% confidence interval (CI) 1.32-2.68, p < 0.001; reference: < 60 mm Hg], partial pressure of oxygen (P

conclusionsBTH was observed during 31% of the monitored time in patients with a large hematoma volume despite the use of a P

Indexed as

Brain tissue hypoxiaBrain tissue normoxiaIntracerebral hemorrhageMultimodal neuromonitoring

Identifiers

PMID42332281

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.