Evidence map›Paper›PMID 42332197›Full record

ArticleThe EMBO journal2026

mRAVE governs lysosomal catabolism through basal and mTORC1-regulated V-ATPase assembly.

Nora S Siefert, Andrea Zanotti, Anastasija Paneva, Martin Schneider, Dominic Helm, Wilhelm Palm

Abstract read
In one paragraph

Article in The EMBO journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Nora S Siefert *Division of Cell Signaling and Metabolism, German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance, Heidelberg, Germany.ORCID http://orcid.org/0000-0002-1101-2264
Andrea Zanotti *Division of Cell Signaling and Metabolism, German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance, Heidelberg, Germany.ORCID http://orcid.org/0000-0001-9789-4300
Anastasija PanevaDivision of Cell Signaling and Metabolism, German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance, Heidelberg, Germany.ORCID http://orcid.org/0009-0005-6982-6905
Martin SchneiderProteomics Core Facility, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID http://orcid.org/0000-0001-5907-3587
Dominic HelmProteomics Core Facility, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Wilhelm PalmDivision of Cell Signaling and Metabolism, German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance, Heidelberg, Germany. w.palm@dkfz-heidelberg.de.ORCID http://orcid.org/0000-0003-0612-770X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acidification of lysosomes, endosomes and the Golgi underpins organelle-specific functions within the endomembrane system. This process is driven by vacuolar-type H

Indexed as

Carrier ProteinsLysosomesMultiprotein ComplexesTOR Serine-Threonine KinasesVacuolar Proton-Translocating ATPasesAnimalsHumansHydrogen-Ion ConcentrationMechanistic Target of Rapamycin Complex 1Nerve Tissue ProteinsBLOC1S1 protein, humanCarrier ProteinsMechanistic Target of Rapamycin Complex 1Multiprotein ComplexesNerve Tissue ProteinsTOR Serine-Threonine KinasesVacuolar Proton-Translocating ATPases

Identifiers

PMID42332197
PMCPMC13534531

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.