Evidence map›Paper›PMID 42332190›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2026

Age and sex-dependent alteration in AMPA receptor density in living human brain.

Mai Hatano, Waki Nakajima, Shohei Tsuchimoto, Tetsu Arisawa, Yuuki Takada, Tsuyoshi Eiro, Hiroki Abe, Sadamitsu Ichijo, Yu Fujimoto, Akane Sano and 19 more

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Article in European journal of nuclear medicine and molecular imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors.

Mai HatanoDepartment of Physiology, Yokohama City University Graduate School of Medicine, Yokohama, 236-0004, Japan.
Waki NakajimaDepartment of Physiology, Yokohama City University Graduate School of Medicine, Yokohama, 236-0004, Japan.
Shohei TsuchimotoDivision of Neural Dynamics, Department of System Neuroscience, National Institute for Physiological Sciences, Okazaki, Aichi, 444-8585, Japan.
Tetsu ArisawaRadioisotope Research Center, Yokohama City University Graduate School of Medicine, Yokohama, 236-0004, Japan.
Yuuki TakadaDepartment of Physiology, Yokohama City University Graduate School of Medicine, Yokohama, 236-0004, Japan.
Tsuyoshi EiroDepartment of Psychiatry, Yokohama City University Graduate School of Medicine, Yokohama, 236-0004, Japan.
Hiroki AbeDepartment of Physiology, Yokohama City University Graduate School of Medicine, Yokohama, 236-0004, Japan.
Sadamitsu IchijoDepartment of Physiology, Yokohama City University Graduate School of Medicine, Yokohama, 236-0004, Japan.
Yu FujimotoDepartment of Physiology, Yokohama City University Graduate School of Medicine, Yokohama, 236-0004, Japan.
Akane SanoDepartment of Physiology, Yokohama City University Graduate School of Medicine, Yokohama, 236-0004, Japan.
Shariful A SyedDepartment of Physiology, Yokohama City University Graduate School of Medicine, Yokohama, 236-0004, Japan.
Hideaki TaniDepartment of Neuropsychiatry, Keio University School of Medicine, Tokyo, 160-8582, Japan.
Nobuhiro NagaiDepartment of Neuropsychiatry, Keio University School of Medicine, Tokyo, 160-8582, Japan.
Teruki KoizumiDepartment of Neuropsychiatry, Keio University School of Medicine, Tokyo, 160-8582, Japan.
Shinichiro NakajimaDepartment of Neuropsychiatry, Keio University School of Medicine, Tokyo, 160-8582, Japan.
Kie Nomoto-TakahashiDepartment of Neuropsychiatry, Keio University School of Medicine, Tokyo, 160-8582, Japan.
Yohei OhtaniDepartment of Neuropsychiatry, Keio University School of Medicine, Tokyo, 160-8582, Japan.
Masahiro JinzakiDepartment of Radiology, Keio University School of Medicine, Tokyo, 160-8582, Japan.
Yoji HiranoDepartment of Psychiatry, Division of Clinical Neuroscience, Faculty of Medicine, University of Miyazaki, Miyazaki, 889-1692, Japan.
Ryo MitomaDepartment of Neuropsychiatry, Graduate School of Medical Sciences, Kyusyu University, Fukuoka, 812-8582, Japan.
Shunsuke TamuraDepartment of Psychiatry, Division of Clinical Neuroscience, Faculty of Medicine, University of Miyazaki, Miyazaki, 889-1692, Japan.
Shingo BabaDepartment of Health Sciences, Graduate School of Medical Sciences, Kyusyu University, Fukuoka, 812-8582, Japan.
Osamu TogaoDepartment of Clinical Radiology, Graduate School of Medical Sciences, Kyusyu University, Fukuoka, 812-8582, Japan.
Hirotaka KosakaDepartment of Neuropsychiatry, School of Medical Sciences, University of Fukui, Fukui, 910-1193, Japan.
Hidehiko OkazawaBiomedical Imaging Research Center, University of Fukui, Fukui, 910-1193, Japan.
Yuichi KimuraFaculty of Informatics, Cyber Informatics Research Institute, Kindai University, Higashi, Osaka, 577-8502, Japan.
Masaru MimuraDepartment of Neuropsychiatry, Keio University School of Medicine, Tokyo, 160-8582, Japan.
Hiroyuki UchidaDepartment of Neuropsychiatry, Keio University School of Medicine, Tokyo, 160-8582, Japan.
Takuya TakahashiDepartment of Physiology, Yokohama City University Graduate School of Medicine, Yokohama, 236-0004, Japan. takahast@yokohama-cu.ac.jp.ORCID 0000-0001-6523-0622

Funding

Japan Agency for Medical Research and Development JP18dm0207023Japan Agency for Medical Research and Development JP20dm0107124Japan Agency for Medical Research and Development JP22dm0207072Japan Agency for Medical Research and Development JP24wm0625302Japan Agency for Medical Research and Development JP24wm0625304Japan Agency for Medical Research and Development JP25gm7010019Japan Society for the Promotion of Science 19H03587Japan Society for the Promotion of Science 20H00549Japan Society for the Promotion of Science 20H05922Japan Society for the Promotion of Science 20K20603Japan Society for the Promotion of Science 20KK0193Japan Society for the Promotion of Science 21H02851Japan Society for the Promotion of Science 22H03001Japan Society for the Promotion of Science 22K15793Japan Society for the Promotion of Science 23K10432Japan Society for the Promotion of Science 25K19145
6 · The paper itself

Abstract

purposeThe excitatory glutamate α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs) play a pivotal role in neurotransmission and neuronal function. However, the effects of age and sex on AMPAR distribution in the living human brain and their associations with cognitive function remain unclear. The purpose of this study was to characterize age- and sex-dependent changes in brain AMPAR density and their relationships with cognitive performance in healthy individuals.

methodsUsing a positron emission tomography tracer for AMPAR, [

resultsAge-dependent differences in cell-surface AMPAR density was observed across most brain regions. Females in their 50 s showed a surge in the upregulation of AMPAR density across brain. Hierarchical clustering revealed five distinct age-related trajectories, featuring marked sex-dependent regional patterns. AMPAR density was positively associated with cognitive performance; delayed memory correlated with whole-brain AMPAR density in both sexes, whereas other cognitive domains showed sex-specific regional associations.

conclusionsThese findings demonstrated age- and sex-related alteration of AMPAR distribution and propose a model of AMPAR related synaptic aging in the living human brain over the life span. Furthermore, they may help to elucidate the pathophysiology of neurodegenerative disorders.

Indexed as

AgingBrainReceptors, AMPASex CharacteristicsAdultAgedCognitionFemaleHumansMaleMiddle AgedPositron-Emission TomographyYoung AdultReceptors, AMPAAMPA receptorPET imagingSynaptic aging

Identifiers

PMID42332190
PMCPMC13526145

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