Evidence map›Paper›PMID 42332137›Full record

ArticleScientific reports2026

Association between soluble Klotho levels and calcification propensity T50 in patients with hemodialysis: a cross-sectional study.

Akio Nakashima, Kazuhiko Kato, Arisa Kobayashi, Rena Kawai, Yuriko Shibata, Saya Tanimoto, Chiharu Aizawa, Keita Kimura, Ichiro Ohkido, Takashi Yokoo

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In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Akio NakashimaDivision of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, 3-25-8, Nishi-shimbashi, Minato-ku, Tokyo, Japan. a-nakashima@jikei.ac.jp.
Kazuhiko KatoDivision of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, 3-25-8, Nishi-shimbashi, Minato-ku, Tokyo, Japan.
Arisa KobayashiDivision of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, 3-25-8, Nishi-shimbashi, Minato-ku, Tokyo, Japan.
Rena KawaiDivision of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, 3-25-8, Nishi-shimbashi, Minato-ku, Tokyo, Japan.
Yuriko ShibataDivision of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, 3-25-8, Nishi-shimbashi, Minato-ku, Tokyo, Japan.
Saya TanimotoDivision of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, 3-25-8, Nishi-shimbashi, Minato-ku, Tokyo, Japan.
Chiharu AizawaDivision of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, 3-25-8, Nishi-shimbashi, Minato-ku, Tokyo, Japan.
Keita KimuraShin-kashiwa Clinic, Chiba, Japan.
Ichiro OhkidoDivision of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, 3-25-8, Nishi-shimbashi, Minato-ku, Tokyo, Japan.
Takashi YokooDivision of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, 3-25-8, Nishi-shimbashi, Minato-ku, Tokyo, Japan.

Funding

JSPS KAKENHI 18K16012, 17K09740, and 23K07727
6 · The paper itself

Abstract

Soluble Klotho is an anti-aging hormone implicated in vascular calcification. The calcification propensity score (T50) is a method used to evaluate the calcification propensity. However, no study has evaluated the association between soluble Klotho and T50. Therefore, this study aimed to investigate the association between soluble Klotho and T50 in patients undergoing hemodialysis. This cross-sectional study recruited patients undergoing hemodialysis. We measured T50 using the turbidimetric method and soluble Klotho using an enzyme-linked immunosorbent assay. Multiple regression analysis was used to examine the association between soluble Klotho and T50. In total, 199 patients were included in this study. Patients' mean age was 65.2 ± 10.2 years, and the median soluble Klotho concentration was 408 (321-525) pg/mL. The serum T50 value was 78 (63-104) minutes. The correlation coefficient between T50 and soluble Klotho was 0.39 (p < 0.001). Multivariate analysis revealed that the T50 value was significantly longer when comparing the group with the lowest and highest Klotho concentrations (β-coefficient = 21.3 [95% confidence interval: 4.5-38.2, p < 0.013]). The analysis of hemodialysis patients revealed for the first time that Klotho is associated with the T50 time. Soluble Klotho may be involved in vascular calcification.

Indexed as

GlucuronidaseRenal DialysisVascular CalcificationAgedBiomarkersCross-Sectional StudiesFemaleHumansKlotho ProteinsMaleMiddle AgedBiomarkersGlucuronidaseKlotho ProteinsKL protein, humanHemodialysisKlothoT50Vascular calcification

Identifiers

PMID42332137
PMCPMC13572464

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.