Evidence map›Paper›PMID 42332088›Full record

ArticleNature methods2026

Derivation of elephant induced pluripotent stem cells.

Evan Appleton, Nataly Korover, Kyunghee Hong, Xochitl Ambriz-Peña, Yoshiaki Tanaka, Asaf Ashkenazy-Titelman, Cody Rasmussen-Ivey, Cristina Rodríguez-Caycedo, Ketaki Bhide, Hao Bai and 32 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature methods, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

42 authors.

Evan AppletonColossal Biosciences, Dallas, TX, USA. evan.appleton@gmail.com.ORCID http://orcid.org/0000-0002-9378-5913
Nataly KoroverColossal Biosciences, Dallas, TX, USA.
Kyunghee HongColossal Biosciences, Dallas, TX, USA.
Xochitl Ambriz-PeñaColossal Biosciences, Dallas, TX, USA.ORCID http://orcid.org/0000-0003-3596-9682
Yoshiaki TanakaColossal Biosciences, Dallas, TX, USA.ORCID http://orcid.org/0000-0002-2078-9374
Asaf Ashkenazy-TitelmanDepartment of Genetics, Harvard Medical School, Boston, MA, USA.
Cody Rasmussen-IveyColossal Biosciences, Dallas, TX, USA.
Cristina Rodríguez-CaycedoColossal Biosciences, Dallas, TX, USA.
Ketaki BhideFormBio, Dallas, TX, USA.
Hao BaiColossal Biosciences, Dallas, TX, USA.
Ana QueirozDepartment of Genetics, Harvard Medical School, Boston, MA, USA.
Jorgen W NelsonColossal Biosciences, Dallas, TX, USA.ORCID http://orcid.org/0000-0002-0202-2460
Grishma RathodColossal Biosciences, Dallas, TX, USA.
Miles MorganColossal Biosciences, Dallas, TX, USA.
Anthony MastracciColossal Biosciences, Dallas, TX, USA.
Theodore M NelsonDepartment of Physiology and Biophysics and the WorldQuant Initiative for Quantitative Prediction, Weill Cornell Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0002-8600-0444
Gregory KnoxColossal Biosciences, Dallas, TX, USA.ORCID http://orcid.org/0009-0006-9442-5641
Brody McNuttFormBio, Dallas, TX, USA.
Nandini MalviyaColossal Biosciences, Dallas, TX, USA.
Kairui ZhangColossal Biosciences, Dallas, TX, USA.
Amanda KowalczykFormBio, Dallas, TX, USA.
Austin BowColossal Biosciences, Dallas, TX, USA.
Bryan McLendonColossal Biosciences, Dallas, TX, USA.ORCID http://orcid.org/0009-0002-3163-3372
Jaroslav SlameckaColossal Biosciences, Dallas, TX, USA.ORCID http://orcid.org/0000-0003-3610-3223
Krista RyonDepartment of Physiology and Biophysics and the WorldQuant Initiative for Quantitative Prediction, Weill Cornell Medicine, New York, NY, USA.
Jackie ProszynskiDepartment of Physiology and Biophysics and the WorldQuant Initiative for Quantitative Prediction, Weill Cornell Medicine, New York, NY, USA.
Nadia HouerbiDepartment of Physiology and Biophysics and the WorldQuant Initiative for Quantitative Prediction, Weill Cornell Medicine, New York, NY, USA.
Ashley S KleinmanDepartment of Physiology and Biophysics and the WorldQuant Initiative for Quantitative Prediction, Weill Cornell Medicine, New York, NY, USA.
Chi-Lam PoonDepartment of Physiology and Biophysics and the WorldQuant Initiative for Quantitative Prediction, Weill Cornell Medicine, New York, NY, USA.
Wendy KisoColossal Biosciences, Dallas, TX, USA.
Matt JamesColossal Biosciences, Dallas, TX, USA.
In-Hyun ParkDepartment of Genetics and Neuroscience, Yale Stem Cell Center, Yale University, New Haven, CT, USA.ORCID http://orcid.org/0000-0001-7748-1293
Charlie GrayAfrican Lion Safari, Hamilton, Ontario, Canada.
Virginia R PearsonFox Chase Cancer Center, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-1903-613X
Christopher E MasonDepartment of Physiology and Biophysics and the WorldQuant Initiative for Quantitative Prediction, Weill Cornell Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0002-1850-1642
Brandi L CantarelColossal Biosciences, Dallas, TX, USA.ORCID http://orcid.org/0000-0003-4126-4478
Karl R KoehlerDepartments of Department of Otolaryngology - Head and Neck Surgery, Harvard Medical School, Boston, MA, USA.
Beth ShapiroColossal Biosciences, Dallas, TX, USA.
James KehlerColossal Biosciences, Dallas, TX, USA.
Ben LammColossal Biosciences, Dallas, TX, USA.
George ChurchDepartment of Genetics, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-6232-9969
Eriona HysolliColossal Biosciences, Dallas, TX, USA. eriona.hysolli@gmail.com.ORCID http://orcid.org/0000-0002-9677-7169

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Biodiversity loss in the present era requires new tools for studying nonmodel organisms. Elephants are both an endangered species and excellent models for studying complex phenotypes including size, social behavior and longevity. Here we report the first derivation of elephant (Elephas maximus) induced pluripotent stem (emiPS) cells. We achieved emiPS cells using two approaches: (1) a two-step process of chemical media induction and colony selection followed by over-expression of elephant transcription factors; and (2) a one-step process with transcription factors and HRAS mutant, HRAS

Indexed as

ElephantsInduced Pluripotent Stem CellsAnimalsCell Culture TechniquesCell DifferentiationCellular ReprogrammingTranscription FactorsTranscription Factors

Identifiers

PMID42332088

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.