Evidence map›Paper›PMID 42332050›Full record

Trial reportJournal of perinatology : official journal of the California Perinatal Association2026

Rates and predictors of intraventricular hemorrhage in the ventfirst trial with comparison to a contemporaneous cohort.

Marya L Strand, Dorothy I Bulas, Susan Niermeyer, Jennifer L Fang, Jamie B Warren, Justin B Josephsen, Monica Epelman, Beth M Kline-Fath, Gina R Petroni, Karen D Fairchild

Registry-linked trialAbstract readMulticenter StudyRandomized Controlled TrialComparative Study
PubMed Publisher
In one paragraph

Trial report in Journal of perinatology : official journal of the California Perinatal Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02742454 (VentFirst), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02742454 naunknown statusnot on this map

VentFirst: A Multicenter RCT of Assisted Ventilation During Delayed Cord Clamping for Extremely Preterm Infants

TypeinterventionalSponsorUniversity of VirginiaRan2016 to 2023Enrolled570ConditionsIntraventricular HemorrhageArmsStandard 30-60 Seconds Cord Clamping, VentFirst 120 Seconds Cord Clamping
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Marya L StrandDepartment of Neonatal-Perinatal Medicine, Akron Children's Hospital, Akron, OH, USA. mstrand@akronchildrens.org.ORCID http://orcid.org/0000-0001-9998-3948
Dorothy I BulasDepartment of Radiology, Children's National Medical Center, Washington, DC, USA.
Susan NiermeyerSection of Neonatology, Department of Pediatrics, University of Colorado, Denver, CO, USA.ORCID http://orcid.org/0000-0001-6310-8519
Jennifer L FangDivision of Neonatal Medicine, Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA.
Jamie B WarrenDivision of Neonatology, Department of Pediatrics, Oregon Health & Science University, Portland, OR, USA.ORCID http://orcid.org/0000-0003-4422-1502
Justin B JosephsenDivision of Neonatology, Department of Pediatrics, Saint Louis University, St Louis, MO, USA.
Monica EpelmanDepartment of Radiology, Nemours Children's Hospital, Orlando, FL, USA.
Beth M Kline-FathDepartment of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.ORCID http://orcid.org/0000-0003-3872-9027
Gina R PetroniDivision of Translational Research and Applied Statistics, Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA.
Karen D FairchildDivision of Neonatology, Department of Pediatrics, University of Virginia, Charlottesville, VA, USA.

Funding

U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) 1R01HD087413
6 · The paper itself

Abstract

objectiveDescribe rates of intraventricular hemorrhage (IVH) in the VentFirst cohort, model risks for severe IVH and compare IVH rates to a contemporaneous population. STUDY

designSub-analysis of the VentFirst multi-center randomized trial.

resultsHead ultrasound findings from 548 infants <29 weeks' gestation who survived to first head ultrasound study in the VentFirst trial were analyzed. Any grade of IVH was found in 31% and severe (grade III/ IV) IVH in 8%. Logistic regression indicated gestational age (GA), twin gestation and 1-minute Apgar as risks for severe IVH. Odds of any IVH and severe IVH were lower in the VentFirst population than in a comparable population in the Vermont Oxford Network.

conclusionSevere IVH in the VentFirst trial was associated with low GA, twin gestation and low 1-minute Apgar score. The lower odds of IVH for the study cohort compared to a similar population may reflect optimized delivery conditions.

trial registrationClinicalTrials.gov Identifier: NCT02742454.

Indexed as

Cerebral HemorrhageCerebral Intraventricular HemorrhageInfant, Premature, DiseasesApgar ScoreFemaleGestational AgeHumansInfant, NewbornInfant, PrematureLogistic ModelsMalePregnancyRisk FactorsUltrasonography

Identifiers

PMID42332050

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.