Evidence map›Paper›PMID 42332044›Full record

ArticleJournal of perinatology : official journal of the California Perinatal Association2026

Systemic glucocorticoid activity in extremely preterm neonates after antenatal betamethasone and intratracheal budesonide: a sub-study of the PLUSS trial.

Mark De Hora, Paul L Hofman, Jeanie Ly Cheong, Peter G Davis, Lex W Doyle, Kate L Francis, C Omar F Kamlin, Brett J Manley, Christopher Jd McKinlay

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Article in Journal of perinatology : official journal of the California Perinatal Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mark De HoraLiggins Institute, University of Auckland, Auckland, New Zealand.
Paul L HofmanLiggins Institute, University of Auckland, Auckland, New Zealand.
Jeanie Ly CheongNewborn Research, The Royal Women's Hospital, Melbourne, VIC, Australia.
Peter G DavisNewborn Research, The Royal Women's Hospital, Melbourne, VIC, Australia.ORCID http://orcid.org/0000-0001-6742-7314
Lex W DoyleNewborn Research, The Royal Women's Hospital, Melbourne, VIC, Australia.ORCID http://orcid.org/0000-0002-7667-7312
Kate L FrancisMurdoch Children's Research Institute, Melbourne, VIC, Australia.ORCID http://orcid.org/0000-0002-1751-5313
C Omar F KamlinNewborn Research, The Royal Women's Hospital, Melbourne, VIC, Australia.
Brett J ManleyDepartment of Obstetrics, Gynaecology and Newborn Health, The University of Melbourne, Melbourne, VIC, Australia.
Christopher Jd McKinlayDepartment of Paediatrics: Child and Youth Health, University of Auckland, Auckland, New Zealand. c.mckinlay@auckland.ac.nz.ORCID http://orcid.org/0000-0003-1088-9467

Funding

Department of Health | National Health and Medical Research Council (NHMRC) GNT1158555
6 · The paper itself

Abstract

objectiveTo quantify systemic exposure to budesonide following intratracheal administration; evaluate the impact of intratracheal budesonide on blood glucocorticoid activity (cortisol plus betamethasone as cortisol equivalents); and relate the latter to outcomes. STUDY

designSub-study of the PLUSS randomized trial(ACTRN12617000322336) of intratracheal budesonide with surfactant versus surfactant alone.

resultAmong 63 infants enrolled at Kidz First Neonatal Care, Auckland, systemic exposure to intratracheal budesonide was low, and cortisol equivalents were similar between intervention groups at 36-48 h (adjusted-ratio-geometric-means = 1.16, 95% CI 0.52-2.57). Antenatal betamethasone <24 h before birth contributed to neonatal blood glucocorticoid activity for up to 24-48 h. Infants above the upper tertile for cortisol equivalents at <60 h, compared with those below the lower tertile, had increased likelihood of severe intraventricular hemorrhage and possibly death.

conclusionSystemic exposure to intratracheal budesonide has little to no effect on cortisol equivalents at 36-48 h. High glucocorticoid activity after birth may be associated with poorer neonatal outcomes.

Identifiers

PMID42332044

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.