Evidence map›Paper›PMID 42332041›Full record

ArticleJournal of perinatology : official journal of the California Perinatal Association2026

Association of parental holding during therapeutic hypothermia and NICU outcomes for infants with hypoxic-ischemic encephalopathy.

Tiana T Nguyen, Hannah C Glass, Natalie Chan, Emily Taketa, Roberta Pineda, Marie-Coralie Cornet, Matthew J Miller

Abstract read
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In one paragraph

Article in Journal of perinatology : official journal of the California Perinatal Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Tiana T NguyenDepartment of Physical Therapy and Rehabilitation Sciences, University of California, San Francisco, CA, USA. tiana.nguyen@ucsf.edu.ORCID http://orcid.org/0009-0005-2672-487X
Hannah C GlassDepartment of Neurology and Weill Institute for Neuroscience, Department of Pediatrics and Benioff Children's Hospital, Department of Epidemiology & Biostatistics, University of California, San Francisco, CA, USA.
Natalie ChanDepartment of Pediatrics and Benioff Children's Hospital, University of California, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-5813-4779
Emily TaketaSchool of Medicine, University of California San Francisco, San Francisco, CA, USA.
Roberta PinedaChan Division of Occupational Science and Occupational Therapy, University of Southern California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0001-9240-4798
Marie-Coralie CornetDepartment of Pediatrics and Benioff Children's Hospital, University of California, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-5233-0800
Matthew J MillerDepartment of Physical Therapy and Rehabilitation Sciences, University of California, San Francisco, CA, USA.

Funding

NRSA Training CoreTL1TR001871 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KANAYA, ALKA M., SOMSOUK, MA · 2016 to 2025
$10.1M
Tailoring Rehabilitation to the needs of Older Adults with Cognitive Impairment and DementiaK76AG083308 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Matthew Miller · 2024 to 2026
$729k
NCATS NIH HHS TL1 TR001871U.S. Department of Health & Human Services | NIH | National Center for Advancing Translational Sciences (NCATS) TL1-TR001871U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) K76AG083308
6 · The paper itself

Abstract

objectiveTo examine associations between parental holding during therapeutic hypothermia (TH) and neonatal intensive care unit (NICU) outcomes among infants with hypoxic-ischemic encephalopathy (HIE). STUDY

designRetrospective cohort of 379 infants with HIE at two level IV NICUs (2017-2024). Unadjusted and adjusted regression models evaluated associations between holding during TH and NICU outcomes.

resultOverall, 28% of infants were held during TH. Holding was less common among infants with greater clinical severity, public insurance, or those identified as Hispanic, Asian, or Black. After adjustment for clinical and sociodemographic factors, holding was associated with faster time to full oral feeding (HR = 1.4, p < 0.01), earlier age at full oral feeding (HR = 1.6, p < 0.01), shorter hospitalization (β = -7.5, p = 0.02), and higher odds of breastmilk feeding at discharge (OR = 3.2, p = 0.03).

conclusionParental holding during TH is associated with favorable short-term NICU outcomes, supporting its potential role as a family-centered care practice during neonatal neurocritical care.

Identifiers

PMID42332041

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.