Evidence map›Paper›PMID 42331979›Full record

ArticleNpj biological timing and sleep2026

Nightmare disorder shows reduced slow oscillation-dominant spindle coupling in NREM sleep.

Istvan Papp, Zoran Cvetkovic, Nazanin Biabani, Jan Rosenzweig, Camilla Speicher, Alessio Delogu, Alexander D Nesbitt, Panagis Drakatos, Ines R Violante, Dijana Vilic and 4 more

Abstract read
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In one paragraph

Article in Npj biological timing and sleep, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Istvan PappSleep and Brain Plasticity Centre, Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College, London, UK.
Zoran CvetkovicDepartment of Engineering, King's College London, London, UK.
Nazanin BiabaniSleep and Brain Plasticity Centre, Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College, London, UK.
Jan RosenzweigDepartment of Engineering, King's College London, London, UK.
Camilla SpeicherSleep and Brain Plasticity Centre, Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College, London, UK.
Alessio DeloguDepartment of Basic and Clinical Neuroscience, IoPPN, King's College London, London, UK.
Alexander D NesbittSleep and Brain Plasticity Centre, Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College, London, UK.
Panagis DrakatosSchool of Basic and Medical Biosciences, Faculty of Life Science and Medicine, King's College, London, UK.
Ines R ViolanteSchool of Biomedical Engineering and Imaging Sciences, King's College London, London, UK.
Dijana VilicClinical Scientific Computing & Medical Physics and Clinical Engineering, Guy's and St Thomas' NHS Foundation Trust, London, UK.
Clive BallardClinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, UK.
David O'ReganSchool of Basic and Medical Biosciences, Faculty of Life Science and Medicine, King's College, London, UK.
Peter J GoadsbyNIHR King's Clinical Research Facility and SLaM Biomedical Research Centre, The Wolfson Sensory, Pain and Regeneration Research Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, King's College Hospital, Wellcome Foundation Building, London, UK.
Ivana RosenzweigSleep and Brain Plasticity Centre, Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College, London, UK. ivana.1.rosenzweig@kcl.ac.uk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nightmare disorder is historically conceptualised as a rapid eye movement (REM) sleep parasomnia, but evidence also points to altered non-rapid eye movement (NREM) sleep physiology. Here, in a retrospective case-control study, we analysed overnight polysomnography from 26 adults with nightmare disorder and 32 controls using a harmonised event-based EEG pipeline. Nightmare disorder showed reduced frontal slow-oscillation-spindle coupling, whereas delta-spindle coupling was preserved, yielding lower coupling dominance than in controls (0.137 ± 0.083 versus 0.238 ± 0.096; p = 6.8 × 10

Identifiers

PMID42331979
PMCPMC13287732

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.