Evidence map›Paper›PMID 42331945›Full record

ArticleScientific reports2026

Two-way tuning of the decidual natural killer cells and recurrent pregnancy loss.

Sergey Petrovich Krechetov, Olga Vladimirovna Khoroshkeeva, Tatyana Eduardovna Yankevich, Yuri Valentinovich Shirokov, Pavel Igorevich Borovikov, Liubov Valentinovna Krechetova, Nana Kartlosovna Tetruashvili, Dmitry Yurievich Trofimov, Gennady Tikhonovich Sukhikh

Abstract read
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In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sergey Petrovich KrechetovLaboratory of Clinical Immunology, National Medical Research Center for Obstetrics, Gynecology and Perinatology Named After Academician V.I.Kulakov, Academician Oparin Street, 4, 117997, Moscow, Russia. s_krechetov@oparina4.ru.
Olga Vladimirovna KhoroshkeevaDepartment of Pregnancy Pathology, National Medical Research Center for Obstetrics, Gynecology and Perinatology Named After Academician V.I.Kulakov, Moscow, Russia.
Tatyana Eduardovna YankevichLaboratory of Human Histocompatibility Genetics, National Research Center Institute of Immunology, Moscow, Russia.
Yuri Valentinovich ShirokovInstitute of the Reproductive Genetics, National Medical Research Center for Obstetrics, Gynecology and Perinatology Named After Academician V.I.Kulakov, Moscow, Russia.
Pavel Igorevich BorovikovLaboratory of Bioinformatics, National Medical Research Center for Obstetrics, Gynecology and Perinatology Named After Academician V.I.Kulakov, Moscow, Russia.
Liubov Valentinovna KrechetovaLaboratory of Clinical Immunology, National Medical Research Center for Obstetrics, Gynecology and Perinatology Named After Academician V.I.Kulakov, Academician Oparin Street, 4, 117997, Moscow, Russia.
Nana Kartlosovna TetruashviliDepartment of Pregnancy Pathology, National Medical Research Center for Obstetrics, Gynecology and Perinatology Named After Academician V.I.Kulakov, Moscow, Russia.
Dmitry Yurievich TrofimovInstitute of the Reproductive Genetics, National Medical Research Center for Obstetrics, Gynecology and Perinatology Named After Academician V.I.Kulakov, Moscow, Russia.
Gennady Tikhonovich SukhikhNational Medical Research Center for Obstetrics, Gynecology and Perinatology Named After Academician V.I.Kulakov, Moscow, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The absence of maternal immune rejection of a haploidentical fetus remains unexplained. We hypothesize that the presence of different HLA antigens on trophoblasts and maternal cells via killer cell immunoglobulin-like receptors (KIRs) provides two-way tuning (education, licensing) of decidual natural killer cells (dNK) with the appearance of alloreactive (HvG) and autoreactive (HvH) dNK. Disturbances in dNK

Indexed as

Abortion, HabitualDeciduaKiller Cells, NaturalFemaleHLA AntigensHumansPlacentaPregnancyReceptors, KIRTrophoblastsHLA AntigensReceptors, KIRDecidual natural killer cellsHLAKiller cell immunoglobulin-like receptorPlacentaRecurrent pregnancy lossTuning

Identifiers

PMID42331945
PMCPMC13575204

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.